A novel model for one-dimensional morphoelasticity. Part II - Application to the contraction of fibroblast-populated collagen lattices
Fibroblast-populated collagen lattices are commonly used in experiments to study the interplay between fibroblasts and their pliable environment. Depending on the method by which they are set, these lattices can contract significantly, in some cases contracting to as little as 10% of their initial l...
| Main Authors: | , , , |
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| Format: | Journal article |
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Springer
2011
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| _version_ | 1826271911199375360 |
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| author | Menon, S Hall, C McCue, S McElwain, D |
| author_facet | Menon, S Hall, C McCue, S McElwain, D |
| author_sort | Menon, S |
| collection | OXFORD |
| description | Fibroblast-populated collagen lattices are commonly used in experiments to study the interplay between fibroblasts and their pliable environment. Depending on the method by which they are set, these lattices can contract significantly, in some cases contracting to as little as 10% of their initial lateral (or vertical) extent. When the reorganisation of such lattices by fibroblasts is interrupted, it has been observed that the gels re-expand slightly but do not return to their original size. In order to describe these phenomena, we apply our theory of one-dimensional morphoelasticity derived in Part I to obtain a system of coupled ordinary differential equations, which we use to describe the behaviour of a fibroblast-populated collagen lattice that is tethered by a spring of known stiffness. We obtain approximate solutions that describe the behaviour of the system at short times as well as those that are valid for long times. We also obtain an exact description of the behaviour of the system in the case where the lattice reorganisation is interrupted. In addition, we perform a perturbation analysis in the limit of large spring stiffness to obtain inner and outer asymptotic expansions for the solution, and examine the relation between force and traction stress in this limit. Finally, we compare predicted numerical values for the initial stiffness and viscosity of the gel with corresponding values for previously obtained sets of experimental data and also compare the qualitative behaviour with that of our model in each case. We find that our model captures many features of the observed behaviour of fibroblast-populated collagen lattices. |
| first_indexed | 2024-03-06T22:04:11Z |
| format | Journal article |
| id | oxford-uuid:4f99c82d-53dc-4767-8c9e-f5eaff1a6a19 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T22:04:11Z |
| publishDate | 2011 |
| publisher | Springer |
| record_format | dspace |
| spelling | oxford-uuid:4f99c82d-53dc-4767-8c9e-f5eaff1a6a192022-03-26T16:08:15ZA novel model for one-dimensional morphoelasticity. Part II - Application to the contraction of fibroblast-populated collagen latticesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4f99c82d-53dc-4767-8c9e-f5eaff1a6a19Mathematical Institute - ePrintsSpringer2011Menon, SHall, CMcCue, SMcElwain, DFibroblast-populated collagen lattices are commonly used in experiments to study the interplay between fibroblasts and their pliable environment. Depending on the method by which they are set, these lattices can contract significantly, in some cases contracting to as little as 10% of their initial lateral (or vertical) extent. When the reorganisation of such lattices by fibroblasts is interrupted, it has been observed that the gels re-expand slightly but do not return to their original size. In order to describe these phenomena, we apply our theory of one-dimensional morphoelasticity derived in Part I to obtain a system of coupled ordinary differential equations, which we use to describe the behaviour of a fibroblast-populated collagen lattice that is tethered by a spring of known stiffness. We obtain approximate solutions that describe the behaviour of the system at short times as well as those that are valid for long times. We also obtain an exact description of the behaviour of the system in the case where the lattice reorganisation is interrupted. In addition, we perform a perturbation analysis in the limit of large spring stiffness to obtain inner and outer asymptotic expansions for the solution, and examine the relation between force and traction stress in this limit. Finally, we compare predicted numerical values for the initial stiffness and viscosity of the gel with corresponding values for previously obtained sets of experimental data and also compare the qualitative behaviour with that of our model in each case. We find that our model captures many features of the observed behaviour of fibroblast-populated collagen lattices. |
| spellingShingle | Menon, S Hall, C McCue, S McElwain, D A novel model for one-dimensional morphoelasticity. Part II - Application to the contraction of fibroblast-populated collagen lattices |
| title | A novel model for one-dimensional morphoelasticity. Part II - Application to the contraction of fibroblast-populated collagen lattices |
| title_full | A novel model for one-dimensional morphoelasticity. Part II - Application to the contraction of fibroblast-populated collagen lattices |
| title_fullStr | A novel model for one-dimensional morphoelasticity. Part II - Application to the contraction of fibroblast-populated collagen lattices |
| title_full_unstemmed | A novel model for one-dimensional morphoelasticity. Part II - Application to the contraction of fibroblast-populated collagen lattices |
| title_short | A novel model for one-dimensional morphoelasticity. Part II - Application to the contraction of fibroblast-populated collagen lattices |
| title_sort | novel model for one dimensional morphoelasticity part ii application to the contraction of fibroblast populated collagen lattices |
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