Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms.

Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms.

NF-kappaB transcription factors induce pro-inflammatory molecules (e.g. IL-8) in response to cytokines (e.g. TNFalpha, IL-1beta) or other stimuli. In the basal state, they are sequestered in the cytoplasm by inhibitory IkappaB proteins. Pro-inflammatory signaling triggers polyubiquitination of inter...

Bibliografiset tiedot
Päätekijät:	Enesa, K, Ito, K, Luong, L, Thorbjornsen, I, Phua, C, To, Y, Dean, J, Haskard, DO, Boyle, J, Adcock, I, Evans, P
Aineistotyyppi:	Journal article
Kieli:	English
Julkaistu:	2008

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