Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms.

NF-kappaB transcription factors induce pro-inflammatory molecules (e.g. IL-8) in response to cytokines (e.g. TNFalpha, IL-1beta) or other stimuli. In the basal state, they are sequestered in the cytoplasm by inhibitory IkappaB proteins. Pro-inflammatory signaling triggers polyubiquitination of inter...

詳細記述

書誌詳細
主要な著者: Enesa, K, Ito, K, Luong, L, Thorbjornsen, I, Phua, C, To, Y, Dean, J, Haskard, DO, Boyle, J, Adcock, I, Evans, P
フォーマット: Journal article
言語:English
出版事項: 2008