Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming
Silencing of the somatic cell type-specific genes is a critical yet poorly understood step in reprogramming. To uncover pathways that maintain cell identity, we performed a reprogramming screen using inhibitors of chromatin factors. Here, we identify acetyl-lysine competitive inhibitors targeting th...
| Κύριοι συγγραφείς: | , , , , , , , , , , , |
|---|---|
| Μορφή: | Journal article |
| Έκδοση: |
Springer Nature
2019
|