Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming
Silencing of the somatic cell type-specific genes is a critical yet poorly understood step in reprogramming. To uncover pathways that maintain cell identity, we performed a reprogramming screen using inhibitors of chromatin factors. Here, we identify acetyl-lysine competitive inhibitors targeting th...
| Príomhchruthaitheoirí: | , , , , , , , , , , , |
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| Formáid: | Journal article |
| Foilsithe / Cruthaithe: |
Springer Nature
2019
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