HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability.

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability.

Individuals with hemizygous germline fumarate hydratase (FH) mutations are predisposed to renal cancer. These tumors predominantly exhibit functional inactivation of the remaining wild-type allele, implicating FH inactivation as a tumor-promoting event. Hypoxia-inducible factors are expressed in man...

תיאור מלא

מידע ביבליוגרפי
Main Authors:	Isaacs, J, Jung, Y, Mole, D, Lee, S, Torres-Cabala, C, Chung, Y, Merino, M, Trepel, J, Zbar, B, Toro, J, Ratcliffe, P, Linehan, WM, Neckers, L
פורמט:	Journal article
שפה:	English
יצא לאור:	2005

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