Utilizing functional genomics screening to identify potentially novel drug targets in cancer cell spheroid cultures

Utilizing functional genomics screening to identify potentially novel drug targets in cancer cell spheroid cultures

The identification of functional driver events in cancer is central to furthering our understanding of cancer biology and indispensable for the discovery of the next generation of novel drug targets. It is becoming apparent that more complex models of cancer are required to fully appreciate the cont...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Morrison, E, Wai, P, Leonidou, A, Bland, P, Khalique, S, Farnie, G, Daley, F, Peck, B, Natrajan, R
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	Journal of Visualized Experiments 2016

Antzeko izenburuak

Three-dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model.
nork: Maguire, S, et al.
Argitaratua: (2016)

A screen to identify drug resistant variants to target-directed anti-cancer agents
nork: Azam Mohammad, et al.
Argitaratua: (2003-01-01)

Formation of miniaturized 3D tumour spheroids for drug screening
nork: Cheah, Cheryl Jia Le
Argitaratua: (2019)

Recent Advances in Multicellular Tumor Spheroid Generation for Drug Screening
nork: Kwang-Ho Lee, et al.
Argitaratua: (2021-11-01)

Characterization of glioblastoma spheroid models for drug screening and phototherapy assays
nork: Samara Rodrigues Alves, et al.
Argitaratua: (2023-01-01)

Rapid and reproducible generation of glioblastoma spheroids for high-throughput drug screening
nork: Christian Bach, et al.
Argitaratua: (2024-12-01)

Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease.
nork: Shilpi Khare, et al.
Argitaratua: (2015-07-01)

Utilization of genomic signatures to identify phenotype-specific drugs.
nork: Seiichi Mori, et al.
Argitaratua: (2009-08-01)

Three-dimensional perfused tumour spheroid model for anti-cancer drug screening
nork: Wan, X, et al.
Argitaratua: (2016)

Automated Uniform Spheroid Generation Platform for High Throughput Drug Screening Process
nork: Kelvin C. C. Pong, et al.
Argitaratua: (2024-08-01)

Spheroids and organoids derived from colorectal cancer as tools for in vitro drug screening
nork: Sahira Syamimi Ahmad Zawawi, et al.
Argitaratua: (2024-04-01)

A polysaccharide-based hydrogel platform for tumor spheroid production and anticancer drug screening
nork: Elliot Lopez-Vince, et al.
Argitaratua: (2025-02-01)

Tailoring esophageal tumor spheroids on a chip with inverse opal scaffolds for drug screening
nork: Ruolin Shi, et al.
Argitaratua: (2024-01-01)

Treatment Efficiency of Free and Nanoparticle-Loaded Mitoxantrone for Magnetic Drug Targeting in Multicellular Tumor Spheroids
nork: Annkathrin Hornung, et al.
Argitaratua: (2015-09-01)

Magnetic 3D bioprinting of skeletal muscle spheroid for a spheroid-based screening assay
nork: Chayanit Chaweewannakorn, et al.
Argitaratua: (2024-12-01)

A proximity proteomics screen in three-dimensional spheroid cultures identifies novel regulators of lumen formation
nork: Li-Ting Wang, et al.
Argitaratua: (2021-11-01)

Manipulating Magnetic 3D Spheroids in Hanging Drops for Applications in Tissue Engineering and Drug Screening
nork: Ho, Vincent H. B., et al.
Argitaratua: (2016)

Spheroids of FAP-Positive Cell Lines as a Model for Screening Drugs That Affect FAP Expression
nork: Victor V. Pleshkan, et al.
Argitaratua: (2023-07-01)

Uniform Tumor Spheroids on Surface-Optimized Microfluidic Biochips for Reproducible Drug Screening and Personalized Medicine
nork: Neda Azizipour, et al.
Argitaratua: (2022-04-01)

Combinatorial drug screening on 3D Ewing sarcoma spheroids using droplet-based microfluidics
nork: Romain Fevre, et al.
Argitaratua: (2023-05-01)

Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening
nork: Millard M, et al.
Argitaratua: (2017-10-01)

Multiplexing spheroid volume, resazurin and acid phosphatase viability assays for high-throughput screening of tumour spheroids and stem cell neurospheres.
nork: Delyan P Ivanov, et al.
Argitaratua: (2014-01-01)

Development of a Magnetic 3D Spheroid Platform with Potential Application for High-Throughput Drug Screening
nork: Guo, Wei Mei, et al.
Argitaratua: (2016)

Therapeutic Potential of CUDC-907 (Fimepinostat) for Hepatocarcinoma Treatment Revealed by Tumor Spheroids-Based Drug Screening
nork: Wei Liao, et al.
Argitaratua: (2021-10-01)

CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response
nork: Karol Szlachta, et al.
Argitaratua: (2018-10-01)

Virtual target screening to rapidly identify potential protein targets of natural products in drug discovery
nork: Yuri Pevzner, et al.
Argitaratua: (2015-08-01)

Network-based screening identifies sitagliptin as an antitumor drug targeting dendritic cells
nork: Zheng Huang, et al.
Argitaratua: (2024-03-01)

Identifying novel potential drug targets for endometriosis via plasma proteome screening
nork: Tian Tao, et al.
Argitaratua: (2024-07-01)

12621 Targeted Chemical-Genetic Screen Platform for Identifying Drug Modes-of-Action
nork: Kevin Lin, et al.
Argitaratua: (2021-03-01)

A Microfluidic Spheroid Culture Device with a Concentration Gradient Generator for High-Throughput Screening of Drug Efficacy
nork: Wanyoung Lim, et al.
Argitaratua: (2018-12-01)

GlomSpheres as a 3D co-culture spheroid model of the kidney glomerulus for rapid drug-screening
nork: Jack Tuffin, et al.
Argitaratua: (2021-12-01)

Morphological Response in Cancer Spheroids for Screening Photodynamic Therapy Parameters
nork: Jose R. Aguilar Cosme, et al.
Argitaratua: (2021-11-01)

Spheroids as 3D Cell Models for Testing of Drugs
nork: Nováková E., et al.
Argitaratua: (2023-08-01)

Cancer cell spheroids are a better screen for the photodynamic efficiency of glycosylated photosensitizers.
nork: Patrícia M R Pereira, et al.
Argitaratua: (2017-01-01)

Kinetics of pearlite spheroidization
nork: Matusiewicz P., et al.
Argitaratua: (2017-03-01)

Protocol for 3D screening of lung cancer spheroids using natural products
nork: Virneliz Fernández Vega, et al.
Argitaratua: (2023-03-01)

Identification of therapeutic sensitivities in a spheroid drug combination screen of Neurofibromatosis Type I associated High Grade Gliomas.
nork: Jacquelyn Dougherty, et al.
Argitaratua: (2023-01-01)

Comparative Analysis of 3D Bladder Tumor Spheroids Obtained by Forced Floating and Hanging Drop Methods for Drug Screening
nork: Robson L. F. Amaral, et al.
Argitaratua: (2017-08-01)

Human Melanocyte-Derived Spheroids: A Precise Test System for Drug Screening and a Multicellular Unit for Tissue Engineering
nork: Irina M. Zurina, et al.
Argitaratua: (2020-06-01)

Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets.
nork: Ulrike S Eggert, et al.
Argitaratua: (2004-12-01)