Utilizing functional genomics screening to identify potentially novel drug targets in cancer cell spheroid cultures

Utilizing functional genomics screening to identify potentially novel drug targets in cancer cell spheroid cultures

The identification of functional driver events in cancer is central to furthering our understanding of cancer biology and indispensable for the discovery of the next generation of novel drug targets. It is becoming apparent that more complex models of cancer are required to fully appreciate the cont...

Bibliografiset tiedot
Päätekijät:	Morrison, E, Wai, P, Leonidou, A, Bland, P, Khalique, S, Farnie, G, Daley, F, Peck, B, Natrajan, R
Aineistotyyppi:	Journal article
Kieli:	English
Julkaistu:	Journal of Visualized Experiments 2016

Samankaltaisia teoksia

Three-dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model.
Tekijä: Maguire, S, et al.
Julkaistu: (2016)

A screen to identify drug resistant variants to target-directed anti-cancer agents
Tekijä: Azam Mohammad, et al.
Julkaistu: (2003-01-01)

Formation of miniaturized 3D tumour spheroids for drug screening
Tekijä: Cheah, Cheryl Jia Le
Julkaistu: (2019)

Recent Advances in Multicellular Tumor Spheroid Generation for Drug Screening
Tekijä: Kwang-Ho Lee, et al.
Julkaistu: (2021-11-01)

Characterization of glioblastoma spheroid models for drug screening and phototherapy assays
Tekijä: Samara Rodrigues Alves, et al.
Julkaistu: (2023-01-01)

Rapid and reproducible generation of glioblastoma spheroids for high-throughput drug screening
Tekijä: Christian Bach, et al.
Julkaistu: (2024-12-01)

Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease.
Tekijä: Shilpi Khare, et al.
Julkaistu: (2015-07-01)

Utilization of genomic signatures to identify phenotype-specific drugs.
Tekijä: Seiichi Mori, et al.
Julkaistu: (2009-08-01)

Three-dimensional perfused tumour spheroid model for anti-cancer drug screening
Tekijä: Wan, X, et al.
Julkaistu: (2016)

Automated Uniform Spheroid Generation Platform for High Throughput Drug Screening Process
Tekijä: Kelvin C. C. Pong, et al.
Julkaistu: (2024-08-01)

Spheroids and organoids derived from colorectal cancer as tools for in vitro drug screening
Tekijä: Sahira Syamimi Ahmad Zawawi, et al.
Julkaistu: (2024-04-01)

A polysaccharide-based hydrogel platform for tumor spheroid production and anticancer drug screening
Tekijä: Elliot Lopez-Vince, et al.
Julkaistu: (2025-02-01)

Tailoring esophageal tumor spheroids on a chip with inverse opal scaffolds for drug screening
Tekijä: Ruolin Shi, et al.
Julkaistu: (2024-01-01)

Treatment Efficiency of Free and Nanoparticle-Loaded Mitoxantrone for Magnetic Drug Targeting in Multicellular Tumor Spheroids
Tekijä: Annkathrin Hornung, et al.
Julkaistu: (2015-09-01)

Magnetic 3D bioprinting of skeletal muscle spheroid for a spheroid-based screening assay
Tekijä: Chayanit Chaweewannakorn, et al.
Julkaistu: (2024-12-01)

A proximity proteomics screen in three-dimensional spheroid cultures identifies novel regulators of lumen formation
Tekijä: Li-Ting Wang, et al.
Julkaistu: (2021-11-01)

Manipulating Magnetic 3D Spheroids in Hanging Drops for Applications in Tissue Engineering and Drug Screening
Tekijä: Ho, Vincent H. B., et al.
Julkaistu: (2016)

Spheroids of FAP-Positive Cell Lines as a Model for Screening Drugs That Affect FAP Expression
Tekijä: Victor V. Pleshkan, et al.
Julkaistu: (2023-07-01)

Uniform Tumor Spheroids on Surface-Optimized Microfluidic Biochips for Reproducible Drug Screening and Personalized Medicine
Tekijä: Neda Azizipour, et al.
Julkaistu: (2022-04-01)

Combinatorial drug screening on 3D Ewing sarcoma spheroids using droplet-based microfluidics
Tekijä: Romain Fevre, et al.
Julkaistu: (2023-05-01)

Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening
Tekijä: Millard M, et al.
Julkaistu: (2017-10-01)

Multiplexing spheroid volume, resazurin and acid phosphatase viability assays for high-throughput screening of tumour spheroids and stem cell neurospheres.
Tekijä: Delyan P Ivanov, et al.
Julkaistu: (2014-01-01)

Development of a Magnetic 3D Spheroid Platform with Potential Application for High-Throughput Drug Screening
Tekijä: Guo, Wei Mei, et al.
Julkaistu: (2016)

Therapeutic Potential of CUDC-907 (Fimepinostat) for Hepatocarcinoma Treatment Revealed by Tumor Spheroids-Based Drug Screening
Tekijä: Wei Liao, et al.
Julkaistu: (2021-10-01)

CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response
Tekijä: Karol Szlachta, et al.
Julkaistu: (2018-10-01)

Virtual target screening to rapidly identify potential protein targets of natural products in drug discovery
Tekijä: Yuri Pevzner, et al.
Julkaistu: (2015-08-01)

Network-based screening identifies sitagliptin as an antitumor drug targeting dendritic cells
Tekijä: Zheng Huang, et al.
Julkaistu: (2024-03-01)

Identifying novel potential drug targets for endometriosis via plasma proteome screening
Tekijä: Tian Tao, et al.
Julkaistu: (2024-07-01)

12621 Targeted Chemical-Genetic Screen Platform for Identifying Drug Modes-of-Action
Tekijä: Kevin Lin, et al.
Julkaistu: (2021-03-01)

A Microfluidic Spheroid Culture Device with a Concentration Gradient Generator for High-Throughput Screening of Drug Efficacy
Tekijä: Wanyoung Lim, et al.
Julkaistu: (2018-12-01)

GlomSpheres as a 3D co-culture spheroid model of the kidney glomerulus for rapid drug-screening
Tekijä: Jack Tuffin, et al.
Julkaistu: (2021-12-01)

Morphological Response in Cancer Spheroids for Screening Photodynamic Therapy Parameters
Tekijä: Jose R. Aguilar Cosme, et al.
Julkaistu: (2021-11-01)

Spheroids as 3D Cell Models for Testing of Drugs
Tekijä: Nováková E., et al.
Julkaistu: (2023-08-01)

Cancer cell spheroids are a better screen for the photodynamic efficiency of glycosylated photosensitizers.
Tekijä: Patrícia M R Pereira, et al.
Julkaistu: (2017-01-01)

Kinetics of pearlite spheroidization
Tekijä: Matusiewicz P., et al.
Julkaistu: (2017-03-01)

Protocol for 3D screening of lung cancer spheroids using natural products
Tekijä: Virneliz Fernández Vega, et al.
Julkaistu: (2023-03-01)

Identification of therapeutic sensitivities in a spheroid drug combination screen of Neurofibromatosis Type I associated High Grade Gliomas.
Tekijä: Jacquelyn Dougherty, et al.
Julkaistu: (2023-01-01)

Comparative Analysis of 3D Bladder Tumor Spheroids Obtained by Forced Floating and Hanging Drop Methods for Drug Screening
Tekijä: Robson L. F. Amaral, et al.
Julkaistu: (2017-08-01)

Human Melanocyte-Derived Spheroids: A Precise Test System for Drug Screening and a Multicellular Unit for Tissue Engineering
Tekijä: Irina M. Zurina, et al.
Julkaistu: (2020-06-01)

Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets.
Tekijä: Ulrike S Eggert, et al.
Julkaistu: (2004-12-01)