Synthesis of cyclic adenosine 5'-diphosphate ribose analogues: a C2'endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor.
Novel 8-substituted base and sugar-modified analogues of the Ca(2+) mobilizing second messenger cyclic adenosine 5'-diphosphate ribose (cADPR) were synthesized using a chemoenzymatic approach and evaluated for activity in sea urchin egg homogenate (SUH) and in Jurkat T-lymphocytes; conformation...
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Bibliographic Details
| Main Authors: |
Moreau, C,
Ashamu, G,
Bailey, VC,
Galione, A,
Guse, A,
Potter, B |
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| Format: | Journal article
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| Language: | English |
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| Published: |
2011
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