Synthesis of cyclic adenosine 5'-diphosphate ribose analogues: a C2'endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor.
Novel 8-substituted base and sugar-modified analogues of the Ca(2+) mobilizing second messenger cyclic adenosine 5'-diphosphate ribose (cADPR) were synthesized using a chemoenzymatic approach and evaluated for activity in sea urchin egg homogenate (SUH) and in Jurkat T-lymphocytes; conformation...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1826271935926894592 |
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| author | Moreau, C Ashamu, G Bailey, VC Galione, A Guse, A Potter, B |
| author_facet | Moreau, C Ashamu, G Bailey, VC Galione, A Guse, A Potter, B |
| author_sort | Moreau, C |
| collection | OXFORD |
| description | Novel 8-substituted base and sugar-modified analogues of the Ca(2+) mobilizing second messenger cyclic adenosine 5'-diphosphate ribose (cADPR) were synthesized using a chemoenzymatic approach and evaluated for activity in sea urchin egg homogenate (SUH) and in Jurkat T-lymphocytes; conformational analysis investigated by (1)H NMR spectroscopy revealed that a C2'endo/syn conformation of the "southern" ribose is crucial for agonist or antagonist activity at the SUH-, but not at the T cell-cADPR receptor. |
| first_indexed | 2024-03-06T22:04:35Z |
| format | Journal article |
| id | oxford-uuid:4fb7f9c8-8eb4-4f89-9e07-d3df13f6d40e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:04:35Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:4fb7f9c8-8eb4-4f89-9e07-d3df13f6d40e2022-03-26T16:09:05ZSynthesis of cyclic adenosine 5'-diphosphate ribose analogues: a C2'endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4fb7f9c8-8eb4-4f89-9e07-d3df13f6d40eEnglishSymplectic Elements at Oxford2011Moreau, CAshamu, GBailey, VCGalione, AGuse, APotter, BNovel 8-substituted base and sugar-modified analogues of the Ca(2+) mobilizing second messenger cyclic adenosine 5'-diphosphate ribose (cADPR) were synthesized using a chemoenzymatic approach and evaluated for activity in sea urchin egg homogenate (SUH) and in Jurkat T-lymphocytes; conformational analysis investigated by (1)H NMR spectroscopy revealed that a C2'endo/syn conformation of the "southern" ribose is crucial for agonist or antagonist activity at the SUH-, but not at the T cell-cADPR receptor. |
| spellingShingle | Moreau, C Ashamu, G Bailey, VC Galione, A Guse, A Potter, B Synthesis of cyclic adenosine 5'-diphosphate ribose analogues: a C2'endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor. |
| title | Synthesis of cyclic adenosine 5'-diphosphate ribose analogues: a C2'endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor. |
| title_full | Synthesis of cyclic adenosine 5'-diphosphate ribose analogues: a C2'endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor. |
| title_fullStr | Synthesis of cyclic adenosine 5'-diphosphate ribose analogues: a C2'endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor. |
| title_full_unstemmed | Synthesis of cyclic adenosine 5'-diphosphate ribose analogues: a C2'endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor. |
| title_short | Synthesis of cyclic adenosine 5'-diphosphate ribose analogues: a C2'endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor. |
| title_sort | synthesis of cyclic adenosine 5 diphosphate ribose analogues a c2 endo syn southern ribose conformation underlies activity at the sea urchin cadpr receptor |
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