Synthesis of cyclic adenosine 5'-diphosphate ribose analogues: a C2'endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor.

Novel 8-substituted base and sugar-modified analogues of the Ca(2+) mobilizing second messenger cyclic adenosine 5'-diphosphate ribose (cADPR) were synthesized using a chemoenzymatic approach and evaluated for activity in sea urchin egg homogenate (SUH) and in Jurkat T-lymphocytes; conformation...

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Những tác giả chính: Moreau, C, Ashamu, G, Bailey, VC, Galione, A, Guse, A, Potter, B
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2011