Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.

Mutations in PIK3CA are very frequent in cancer and lead to sustained PI3K pathway activation. The impact of acute expression of mutant PIK3CA during early stages of malignancy is unknown. Using a mouse model to activate the Pik3ca H1047R hotspot mutation in the heterozygous state from its endogenou...

Full description

Bibliographic Details
Main Authors: Berenjeno, I, Piñeiro, R, Castillo, S, Pearce, W, McGranahan, N, Dewhurst, S, Meniel, V, Birkbak, N, Lau, E, Sansregret, L, Morelli, D, Kanu, N, Srinivas, S, Graupera, M, Parker, V, Montgomery, K, Moniz, L, Scudamore, C, Phillips, W, Semple, R, Clarke, A, Swanton, C, Vanhaesebroeck, B
Format: Journal article
Language:English
Published: Nature Publishing Group 2017

Similar Items

Similar Items