Peptidomimetic bond formation by DNA-templated acyl transfer.
The efficiencies of DNA-templated acyl transfer reactions between a thioester modified oligonucleotide and a series of amine and thiol based nucleophiles are directly compared. The reactivity of the nucleophile, reaction conditions (solvent, buffer, pH) and linker length all play important roles in...
| Main Authors: | , , , , , |
|---|---|
| 格式: | Journal article |
| 語言: | English |
| 出版: |
2011
|