Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory
Dietary magnesium (Mg<sup>2+</sup>) supplementation can enhance memory in young and aged rats. Memory-enhancing capacity was largely ascribed to increases in hippocampal synaptic density and elevated expression of the NR2B subunit of the NMDA-type glutamate receptor. Here we show that Mg...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
eLife Sciences Publications
2020
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| _version_ | 1797068048802250752 |
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| author | Wu, Y Funato, Y Meschi, E Jovanoski, KD Miki, H Waddell, S |
| author_facet | Wu, Y Funato, Y Meschi, E Jovanoski, KD Miki, H Waddell, S |
| author_sort | Wu, Y |
| collection | OXFORD |
| description | Dietary magnesium (Mg<sup>2+</sup>) supplementation can enhance memory in young and aged rats. Memory-enhancing capacity was largely ascribed to increases in hippocampal synaptic density and elevated expression of the NR2B subunit of the NMDA-type glutamate receptor. Here we show that Mg<sup>2+</sup> feeding also enhances long-term memory in Drosophila. Normal and Mg<sup>2+</sup>-enhanced fly memory appears independent of NMDA receptors in the mushroom body and instead requires expression of a conserved CNNM-type Mg<sup>2+</sup>-efflux transporter encoded by the unextended (uex) gene. UEX contains a putative cyclic nucleotide-binding homology domain and its mutation separates a vital role for uex from a function in memory. Moreover, UEX localization in mushroom body Kenyon cells (KCs) is altered in memory-defective flies harboring mutations in cAMP-related genes. Functional imaging suggests that UEX-dependent efflux is required for slow rhythmic maintenance of KC Mg<sup>2+</sup>. We propose that regulated neuronal Mg<sup>2+</sup> efflux is critical for normal and Mg<sup>2+</sup>-enhanced memory. |
| first_indexed | 2024-03-06T22:05:07Z |
| format | Journal article |
| id | oxford-uuid:4fdefdef-ec5a-4f71-8197-47a40140964f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:05:07Z |
| publishDate | 2020 |
| publisher | eLife Sciences Publications |
| record_format | dspace |
| spelling | oxford-uuid:4fdefdef-ec5a-4f71-8197-47a40140964f2022-03-26T16:10:27ZMagnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memoryJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4fdefdef-ec5a-4f71-8197-47a40140964fEnglishSymplectic ElementseLife Sciences Publications2020Wu, YFunato, YMeschi, EJovanoski, KDMiki, HWaddell, SDietary magnesium (Mg<sup>2+</sup>) supplementation can enhance memory in young and aged rats. Memory-enhancing capacity was largely ascribed to increases in hippocampal synaptic density and elevated expression of the NR2B subunit of the NMDA-type glutamate receptor. Here we show that Mg<sup>2+</sup> feeding also enhances long-term memory in Drosophila. Normal and Mg<sup>2+</sup>-enhanced fly memory appears independent of NMDA receptors in the mushroom body and instead requires expression of a conserved CNNM-type Mg<sup>2+</sup>-efflux transporter encoded by the unextended (uex) gene. UEX contains a putative cyclic nucleotide-binding homology domain and its mutation separates a vital role for uex from a function in memory. Moreover, UEX localization in mushroom body Kenyon cells (KCs) is altered in memory-defective flies harboring mutations in cAMP-related genes. Functional imaging suggests that UEX-dependent efflux is required for slow rhythmic maintenance of KC Mg<sup>2+</sup>. We propose that regulated neuronal Mg<sup>2+</sup> efflux is critical for normal and Mg<sup>2+</sup>-enhanced memory. |
| spellingShingle | Wu, Y Funato, Y Meschi, E Jovanoski, KD Miki, H Waddell, S Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory |
| title | Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory |
| title_full | Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory |
| title_fullStr | Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory |
| title_full_unstemmed | Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory |
| title_short | Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory |
| title_sort | magnesium efflux from drosophila kenyon cells is critical for normal and diet enhanced long term memory |
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