Alcohol drinking and overall and cause-specific mortality in China: nationally representative prospective study of 220,000 men with 15 years of follow-up.
BACKGROUND: Regular alcohol drinking contributes both favourably and adversely to health in the Western populations, but its effects on overall and cause-specific mortality in China are still poorly understood. METHODS: A nationally representative prospective cohort study included 220,000 men aged 4...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2012
|
| _version_ | 1797068050024890368 |
|---|---|
| author | Yang, L Zhou, M Sherliker, P Cai, Y Peto, R Wang, L Millwood, I Smith, M Hu, Y Yang, G Chen, Z |
| author_facet | Yang, L Zhou, M Sherliker, P Cai, Y Peto, R Wang, L Millwood, I Smith, M Hu, Y Yang, G Chen, Z |
| author_sort | Yang, L |
| collection | OXFORD |
| description | BACKGROUND: Regular alcohol drinking contributes both favourably and adversely to health in the Western populations, but its effects on overall and cause-specific mortality in China are still poorly understood. METHODS: A nationally representative prospective cohort study included 220,000 men aged 40-79 years from 45 areas in China in 1990-91, and >40,000 deaths occurred during 15 years of follow-up. Cox regression was used to relate alcohol drinking to overall and cause-specific mortality, adjusting for age, area, smoking and education. RESULTS: Overall, 33% of the participants reported drinking alcohol regularly at baseline, consuming mainly distilled spirits, with an estimated mean amount consumed of 372 g/week (46.5 units per week). After excluding all men with prior disease at baseline and the first 3 years of follow-up, there was a 5% [95% confidence interval (CI) 2-8] excess risk of overall mortality among regular drinkers. Compared with non-drinkers, the adjusted hazard ratios among men who drank <140, 140-279, 280-419, 420-699 and ≥ 700 g/week were 0.97, 1.00, 1.02, 1.12 and 1.27, respectively (P < 0.0001 for trend). The strength of the relationship appeared to be greater in smokers than in non-smokers. There was a strong positive association of alcohol drinking with mortality from stroke, oesophageal cancer, liver cirrhosis or accidental causes, a weak J-shaped association with mortality from ischaemic heart disease, stomach cancer and lung cancer and no apparent relationship with respiratory disease mortality. CONCLUSION: Among Chinese men aged 40-79 years, regular alcohol drinking was associated with a small but definite excess risk of overall mortality, especially among smokers. |
| first_indexed | 2024-03-06T22:05:08Z |
| format | Journal article |
| id | oxford-uuid:4fe16776-4253-41df-b0e4-9816ac3b9a1d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:05:08Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:4fe16776-4253-41df-b0e4-9816ac3b9a1d2022-03-26T16:10:17ZAlcohol drinking and overall and cause-specific mortality in China: nationally representative prospective study of 220,000 men with 15 years of follow-up.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4fe16776-4253-41df-b0e4-9816ac3b9a1dEnglishSymplectic Elements at Oxford2012Yang, LZhou, MSherliker, PCai, YPeto, RWang, LMillwood, ISmith, MHu, YYang, GChen, ZBACKGROUND: Regular alcohol drinking contributes both favourably and adversely to health in the Western populations, but its effects on overall and cause-specific mortality in China are still poorly understood. METHODS: A nationally representative prospective cohort study included 220,000 men aged 40-79 years from 45 areas in China in 1990-91, and >40,000 deaths occurred during 15 years of follow-up. Cox regression was used to relate alcohol drinking to overall and cause-specific mortality, adjusting for age, area, smoking and education. RESULTS: Overall, 33% of the participants reported drinking alcohol regularly at baseline, consuming mainly distilled spirits, with an estimated mean amount consumed of 372 g/week (46.5 units per week). After excluding all men with prior disease at baseline and the first 3 years of follow-up, there was a 5% [95% confidence interval (CI) 2-8] excess risk of overall mortality among regular drinkers. Compared with non-drinkers, the adjusted hazard ratios among men who drank <140, 140-279, 280-419, 420-699 and ≥ 700 g/week were 0.97, 1.00, 1.02, 1.12 and 1.27, respectively (P < 0.0001 for trend). The strength of the relationship appeared to be greater in smokers than in non-smokers. There was a strong positive association of alcohol drinking with mortality from stroke, oesophageal cancer, liver cirrhosis or accidental causes, a weak J-shaped association with mortality from ischaemic heart disease, stomach cancer and lung cancer and no apparent relationship with respiratory disease mortality. CONCLUSION: Among Chinese men aged 40-79 years, regular alcohol drinking was associated with a small but definite excess risk of overall mortality, especially among smokers. |
| spellingShingle | Yang, L Zhou, M Sherliker, P Cai, Y Peto, R Wang, L Millwood, I Smith, M Hu, Y Yang, G Chen, Z Alcohol drinking and overall and cause-specific mortality in China: nationally representative prospective study of 220,000 men with 15 years of follow-up. |
| title | Alcohol drinking and overall and cause-specific mortality in China: nationally representative prospective study of 220,000 men with 15 years of follow-up. |
| title_full | Alcohol drinking and overall and cause-specific mortality in China: nationally representative prospective study of 220,000 men with 15 years of follow-up. |
| title_fullStr | Alcohol drinking and overall and cause-specific mortality in China: nationally representative prospective study of 220,000 men with 15 years of follow-up. |
| title_full_unstemmed | Alcohol drinking and overall and cause-specific mortality in China: nationally representative prospective study of 220,000 men with 15 years of follow-up. |
| title_short | Alcohol drinking and overall and cause-specific mortality in China: nationally representative prospective study of 220,000 men with 15 years of follow-up. |
| title_sort | alcohol drinking and overall and cause specific mortality in china nationally representative prospective study of 220 000 men with 15 years of follow up |
| work_keys_str_mv | AT yangl alcoholdrinkingandoverallandcausespecificmortalityinchinanationallyrepresentativeprospectivestudyof220000menwith15yearsoffollowup AT zhoum alcoholdrinkingandoverallandcausespecificmortalityinchinanationallyrepresentativeprospectivestudyof220000menwith15yearsoffollowup AT sherlikerp alcoholdrinkingandoverallandcausespecificmortalityinchinanationallyrepresentativeprospectivestudyof220000menwith15yearsoffollowup AT caiy alcoholdrinkingandoverallandcausespecificmortalityinchinanationallyrepresentativeprospectivestudyof220000menwith15yearsoffollowup AT petor alcoholdrinkingandoverallandcausespecificmortalityinchinanationallyrepresentativeprospectivestudyof220000menwith15yearsoffollowup AT wangl alcoholdrinkingandoverallandcausespecificmortalityinchinanationallyrepresentativeprospectivestudyof220000menwith15yearsoffollowup AT millwoodi alcoholdrinkingandoverallandcausespecificmortalityinchinanationallyrepresentativeprospectivestudyof220000menwith15yearsoffollowup AT smithm alcoholdrinkingandoverallandcausespecificmortalityinchinanationallyrepresentativeprospectivestudyof220000menwith15yearsoffollowup AT huy alcoholdrinkingandoverallandcausespecificmortalityinchinanationallyrepresentativeprospectivestudyof220000menwith15yearsoffollowup AT yangg alcoholdrinkingandoverallandcausespecificmortalityinchinanationallyrepresentativeprospectivestudyof220000menwith15yearsoffollowup AT chenz alcoholdrinkingandoverallandcausespecificmortalityinchinanationallyrepresentativeprospectivestudyof220000menwith15yearsoffollowup |