What counts in the immunological synapse?
Molecular interactions at the interface between helper T cells and antigen-presenting B cells govern the ability to produce specific antibodies, which is a central event in protective immunity generated by natural infection or man-made vaccines. In order for a T cell to deliver effective help to a B...
| Main Author: | |
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| Format: | Journal article |
| Language: | English |
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Cell Press
2014
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| _version_ | 1797068052087439360 |
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| author | Dustin, M |
| author_facet | Dustin, M |
| author_sort | Dustin, M |
| collection | OXFORD |
| description | Molecular interactions at the interface between helper T cells and antigen-presenting B cells govern the ability to produce specific antibodies, which is a central event in protective immunity generated by natural infection or man-made vaccines. In order for a T cell to deliver effective help to a B cell and guide affinity maturation, it needs to provide feedback that is proportional to the amount of antigen the B cell collects with its surface antibody. This review focuses on mechanisms by which T and B cells manage to count the products of antigen capture and encourage B cells with the best receptors to dominate the response and make antibody-producing plasma cells. We discuss what is known about the proportionality of T cells responses to presented antigens and consider the mechanisms that B cells may use to keep count of positive feedback from T cells. |
| first_indexed | 2024-03-06T22:05:10Z |
| format | Journal article |
| id | oxford-uuid:4fe35d62-d86f-4b13-83c3-ff6a658f87ec |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:05:10Z |
| publishDate | 2014 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:4fe35d62-d86f-4b13-83c3-ff6a658f87ec2022-03-26T16:10:15ZWhat counts in the immunological synapse?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4fe35d62-d86f-4b13-83c3-ff6a658f87ecEnglishSymplectic Elements at OxfordCell Press2014Dustin, MMolecular interactions at the interface between helper T cells and antigen-presenting B cells govern the ability to produce specific antibodies, which is a central event in protective immunity generated by natural infection or man-made vaccines. In order for a T cell to deliver effective help to a B cell and guide affinity maturation, it needs to provide feedback that is proportional to the amount of antigen the B cell collects with its surface antibody. This review focuses on mechanisms by which T and B cells manage to count the products of antigen capture and encourage B cells with the best receptors to dominate the response and make antibody-producing plasma cells. We discuss what is known about the proportionality of T cells responses to presented antigens and consider the mechanisms that B cells may use to keep count of positive feedback from T cells. |
| spellingShingle | Dustin, M What counts in the immunological synapse? |
| title | What counts in the immunological synapse? |
| title_full | What counts in the immunological synapse? |
| title_fullStr | What counts in the immunological synapse? |
| title_full_unstemmed | What counts in the immunological synapse? |
| title_short | What counts in the immunological synapse? |
| title_sort | what counts in the immunological synapse |
| work_keys_str_mv | AT dustinm whatcountsintheimmunologicalsynapse |