Role for non-proteolytic control of M-phase-promoting factor activity at M-phase exit

Role for non-proteolytic control of M-phase-promoting factor activity at M-phase exit

M-phase Promoting Factor (MPF; the cyclin B-cdk 1 complex) is activated at M-phase onset by removal of inhibitory phosphorylation of cdk1 at thr-14 and tyr-15. At M-phase exit, MPF is destroyed by ubiquitin-dependent cyclin proteolysis. Thus, control of MPF activity via inhibitory phosphorylation is...

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Autors principals:	D'Angiolella, V, Palazzo, L, Santarpia, C, Costanzo, V, Grieco, D
Format:	Journal article
Idioma:	English
Publicat:	Public Library of Science 2007

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