Structural and mechanistic studies on γ-butyrobetaine hydroxylase.

Structural and mechanistic studies on γ-butyrobetaine hydroxylase.

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The final step in carnitine biosynthesis is catalyzed by γ-butyrobetaine (γBB) hydroxylase (BBOX), an iron/2-oxoglutarate (2OG) dependent oxygenase. BBOX is inhibited by trimethylhydrazine-propionate (THP), a clinically used compound. We report structural and mechanistic studies on BBOX and its reac...

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Bibliographic Details
Main Authors:	Leung, I, Krojer, T, Kochan, G, Henry, L, von Delft, F, Claridge, T, Oppermann, U, McDonough, M, Schofield, C
Format:	Journal article
Language:	English
Published:	2010
Subjects:	Carnitine chemistry Crystallography, X-Ray gamma-Butyrobetaine Dioxygenase Substrate Specificity biosynthesis Catalytic Domain metabolism Protein Structure, Quaternary Dimerization Protein Structure, Tertiary

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