Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair
Notch has a well-defined role in controlling cell fate decisions in the embryo and the adult epidermis and immune systems, yet emerging evidence suggests Notch also directs non-cell-autonomous signalling in adult tissues. Here, we show that Notch1 works as a damage response signal. Epidermal Notch i...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Nature Research
2016
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| _version_ | 1797068098888531968 |
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| author | Li, Z Hodgkinson, T Gothard, E Boroumand, S Lamb, R Cummins, I Narang, P Sawtell, A Coles, J Leonov, G Reboldi, A Buckley, C Cupedo, T Siebel, C Bayat, A Coles, M Ambler, C |
| author_facet | Li, Z Hodgkinson, T Gothard, E Boroumand, S Lamb, R Cummins, I Narang, P Sawtell, A Coles, J Leonov, G Reboldi, A Buckley, C Cupedo, T Siebel, C Bayat, A Coles, M Ambler, C |
| author_sort | Li, Z |
| collection | OXFORD |
| description | Notch has a well-defined role in controlling cell fate decisions in the embryo and the adult epidermis and immune systems, yet emerging evidence suggests Notch also directs non-cell-autonomous signalling in adult tissues. Here, we show that Notch1 works as a damage response signal. Epidermal Notch induces recruitment of immune cell subsets including RORγ+ ILC3s into wounded dermis; RORγ+ ILC3s are potent sources of IL17F in wounds and control immunological and epidermal cell responses. Mice deficient for RORγ+ ILC3s heal wounds poorly resulting from delayed epidermal proliferation and macrophage recruitment in a CCL3-dependent process. Notch1 upregulates TNFα and the ILC3 recruitment chemokines CCL20 and CXCL13. TNFα, as a Notch1 effector, directs ILC3 localization and rates of wound healing. Altogether these findings suggest that Notch is a key stress/injury signal in skin epithelium driving innate immune cell recruitment and normal skin tissue repair. |
| first_indexed | 2024-03-06T22:05:47Z |
| format | Journal article |
| id | oxford-uuid:50185503-91b7-4db4-bded-946aee79689c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:05:47Z |
| publishDate | 2016 |
| publisher | Nature Research |
| record_format | dspace |
| spelling | oxford-uuid:50185503-91b7-4db4-bded-946aee79689c2022-03-26T16:11:33ZEpidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repairJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:50185503-91b7-4db4-bded-946aee79689cEnglishSymplectic Elements at OxfordNature Research2016Li, ZHodgkinson, TGothard, EBoroumand, SLamb, RCummins, INarang, PSawtell, AColes, JLeonov, GReboldi, ABuckley, CCupedo, TSiebel, CBayat, AColes, MAmbler, CNotch has a well-defined role in controlling cell fate decisions in the embryo and the adult epidermis and immune systems, yet emerging evidence suggests Notch also directs non-cell-autonomous signalling in adult tissues. Here, we show that Notch1 works as a damage response signal. Epidermal Notch induces recruitment of immune cell subsets including RORγ+ ILC3s into wounded dermis; RORγ+ ILC3s are potent sources of IL17F in wounds and control immunological and epidermal cell responses. Mice deficient for RORγ+ ILC3s heal wounds poorly resulting from delayed epidermal proliferation and macrophage recruitment in a CCL3-dependent process. Notch1 upregulates TNFα and the ILC3 recruitment chemokines CCL20 and CXCL13. TNFα, as a Notch1 effector, directs ILC3 localization and rates of wound healing. Altogether these findings suggest that Notch is a key stress/injury signal in skin epithelium driving innate immune cell recruitment and normal skin tissue repair. |
| spellingShingle | Li, Z Hodgkinson, T Gothard, E Boroumand, S Lamb, R Cummins, I Narang, P Sawtell, A Coles, J Leonov, G Reboldi, A Buckley, C Cupedo, T Siebel, C Bayat, A Coles, M Ambler, C Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair |
| title | Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair |
| title_full | Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair |
| title_fullStr | Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair |
| title_full_unstemmed | Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair |
| title_short | Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair |
| title_sort | epidermal notch1 recruits rorγ group 3 innate lymphoid cells to orchestrate normal skin repair |
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