Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair
Notch has a well-defined role in controlling cell fate decisions in the embryo and the adult epidermis and immune systems, yet emerging evidence suggests Notch also directs non-cell-autonomous signalling in adult tissues. Here, we show that Notch1 works as a damage response signal. Epidermal Notch i...
Main Authors: | Li, Z, Hodgkinson, T, Gothard, E, Boroumand, S, Lamb, R, Cummins, I, Narang, P, Sawtell, A, Coles, J, Leonov, G, Reboldi, A, Buckley, C, Cupedo, T, Siebel, C, Bayat, A, Coles, M, Ambler, C |
---|---|
Format: | Journal article |
Language: | English |
Published: |
Nature Research
2016
|
Similar Items
-
Quantitative methods for measuring repair rates and innate-immune cell responses in wounded mouse skin
by: Li, Z, et al.
Published: (2018) -
RORγt+ innate lymphoid cells promote lymph node metastasis of breast cancers.
by: Irshad, S, et al.
Published: (2017) -
Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage
by: Aparicio-Domingo, P, et al.
Published: (2015) -
Stromal cells in tertiary lymphoid structures: a novel pathogenic paradigm and therapeutic target in Sjogren's syndrome
by: Nayar, S, et al.
Published: (2017) -
The Dichotomous Nature of AZ5104 (an EGFR Inhibitor) Towards RORγ and RORγT
by: Kaja Karaś, et al.
Published: (2019-11-01)