Effects of hydrocortisone on brain 5-HT function and sleep.
The effects of hydrocortisone administration (20 mg, orally, twice daily) on the sensitivity of brain 5-HT1A receptors in healthy volunteers were studied using a buspirone challenge paradigm. The effects of hydrocortisone administration on sleep architecture were also studied. Hydrocortisone treatme...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1994
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| _version_ | 1797068104718614528 |
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| author | Young, A Sharpley, A Campling, G Hockney, R Cowen, P |
| author_facet | Young, A Sharpley, A Campling, G Hockney, R Cowen, P |
| author_sort | Young, A |
| collection | OXFORD |
| description | The effects of hydrocortisone administration (20 mg, orally, twice daily) on the sensitivity of brain 5-HT1A receptors in healthy volunteers were studied using a buspirone challenge paradigm. The effects of hydrocortisone administration on sleep architecture were also studied. Hydrocortisone treatment significantly attenuated the hypothermic and cortisol responses to buspirone; however, the prolactin and growth hormone responses were unchanged. Hydrocortisone also decreased the amount of rapid eye movement sleep (REM). The ability of hydrocortisone to attenuate 5-HT1A receptor mediated hypothermia and decrease REM sleep is shared by certain antidepressant treatments and may be related to the effects of corticosteroids on mood. |
| first_indexed | 2024-03-06T22:05:52Z |
| format | Journal article |
| id | oxford-uuid:501e57ff-0ec5-405d-a3de-78ba77efe6dc |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:05:52Z |
| publishDate | 1994 |
| record_format | dspace |
| spelling | oxford-uuid:501e57ff-0ec5-405d-a3de-78ba77efe6dc2022-03-26T16:11:43ZEffects of hydrocortisone on brain 5-HT function and sleep.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:501e57ff-0ec5-405d-a3de-78ba77efe6dcEnglishSymplectic Elements at Oxford1994Young, ASharpley, ACampling, GHockney, RCowen, PThe effects of hydrocortisone administration (20 mg, orally, twice daily) on the sensitivity of brain 5-HT1A receptors in healthy volunteers were studied using a buspirone challenge paradigm. The effects of hydrocortisone administration on sleep architecture were also studied. Hydrocortisone treatment significantly attenuated the hypothermic and cortisol responses to buspirone; however, the prolactin and growth hormone responses were unchanged. Hydrocortisone also decreased the amount of rapid eye movement sleep (REM). The ability of hydrocortisone to attenuate 5-HT1A receptor mediated hypothermia and decrease REM sleep is shared by certain antidepressant treatments and may be related to the effects of corticosteroids on mood. |
| spellingShingle | Young, A Sharpley, A Campling, G Hockney, R Cowen, P Effects of hydrocortisone on brain 5-HT function and sleep. |
| title | Effects of hydrocortisone on brain 5-HT function and sleep. |
| title_full | Effects of hydrocortisone on brain 5-HT function and sleep. |
| title_fullStr | Effects of hydrocortisone on brain 5-HT function and sleep. |
| title_full_unstemmed | Effects of hydrocortisone on brain 5-HT function and sleep. |
| title_short | Effects of hydrocortisone on brain 5-HT function and sleep. |
| title_sort | effects of hydrocortisone on brain 5 ht function and sleep |
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