Asymptomatic children with multiple endocrine neoplasia type 1 mutations may harbor nonfunctioning pancreatic neuroendocrine tumors.

CONTEXT: Multiple endocrine neoplasia type 1 (MEN1) is characterized by the occurrence of parathyroid, pituitary, and pancreatic tumors. MEN1, an autosomal dominant disorder, has a high degree of penetrance, such that more than 95% of patients develop clinical manifestations by the fifth decade, alt...

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Hlavní autoři: Newey, P, Jeyabalan, J, Walls, G, Christie, P, Gleeson, F, Gould, S, Johnson, P, Phillips, R, Ryan, F, Shine, B, Bowl, MR, Thakker, R
Médium: Journal article
Jazyk:English
Vydáno: 2009