Application of a null-beamformer to source localisation in MEG data of deep brain stimulation.
In this paper, we present an analysis of magnetoencephalography (MEG) signals from a patient with whole-body chronic pain in order to investigate changes in neural activity induced by DBS. The patient is one of the few cases treated using DBS of the anterior cingulate cortex (ACC). Using MEG to reco...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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| _version_ | 1797068127659360256 |
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| author | Mohseni, H Kringelbach, M Probert Smith, P Green, A Parsons, C Young, K Brittain, J Hyam, J Schweder, P Stein, J Aziz, T |
| author_facet | Mohseni, H Kringelbach, M Probert Smith, P Green, A Parsons, C Young, K Brittain, J Hyam, J Schweder, P Stein, J Aziz, T |
| author_sort | Mohseni, H |
| collection | OXFORD |
| description | In this paper, we present an analysis of magnetoencephalography (MEG) signals from a patient with whole-body chronic pain in order to investigate changes in neural activity induced by DBS. The patient is one of the few cases treated using DBS of the anterior cingulate cortex (ACC). Using MEG to reconstruct the neural activity of interest is challenging because of interference to the signal from the DBS device. We demonstrate that a null-beamformer can be used to localise neural activity despite artefacts caused by the presence of DBS electrodes and stimulus pulses. We subsequently verified the accuracy of our source localisation by correlating the predicted DBS electrode positions with their actual positions, previously identified using anatomical imaging. We also demonstrated increased activity in pain-related regions including the pre-supplementary motor area, brainstem periaqueductal gray and medial prefrontal areas when the patient was in pain compared to when the patient experienced pain relief. |
| first_indexed | 2024-03-06T22:06:13Z |
| format | Journal article |
| id | oxford-uuid:503d0732-d9cb-4b1d-9685-6e2c25072655 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:06:13Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:503d0732-d9cb-4b1d-9685-6e2c250726552022-03-26T16:12:22ZApplication of a null-beamformer to source localisation in MEG data of deep brain stimulation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:503d0732-d9cb-4b1d-9685-6e2c25072655EnglishSymplectic Elements at Oxford2010Mohseni, HKringelbach, MProbert Smith, PGreen, AParsons, CYoung, KBrittain, JHyam, JSchweder, PStein, JAziz, TIn this paper, we present an analysis of magnetoencephalography (MEG) signals from a patient with whole-body chronic pain in order to investigate changes in neural activity induced by DBS. The patient is one of the few cases treated using DBS of the anterior cingulate cortex (ACC). Using MEG to reconstruct the neural activity of interest is challenging because of interference to the signal from the DBS device. We demonstrate that a null-beamformer can be used to localise neural activity despite artefacts caused by the presence of DBS electrodes and stimulus pulses. We subsequently verified the accuracy of our source localisation by correlating the predicted DBS electrode positions with their actual positions, previously identified using anatomical imaging. We also demonstrated increased activity in pain-related regions including the pre-supplementary motor area, brainstem periaqueductal gray and medial prefrontal areas when the patient was in pain compared to when the patient experienced pain relief. |
| spellingShingle | Mohseni, H Kringelbach, M Probert Smith, P Green, A Parsons, C Young, K Brittain, J Hyam, J Schweder, P Stein, J Aziz, T Application of a null-beamformer to source localisation in MEG data of deep brain stimulation. |
| title | Application of a null-beamformer to source localisation in MEG data of deep brain stimulation. |
| title_full | Application of a null-beamformer to source localisation in MEG data of deep brain stimulation. |
| title_fullStr | Application of a null-beamformer to source localisation in MEG data of deep brain stimulation. |
| title_full_unstemmed | Application of a null-beamformer to source localisation in MEG data of deep brain stimulation. |
| title_short | Application of a null-beamformer to source localisation in MEG data of deep brain stimulation. |
| title_sort | application of a null beamformer to source localisation in meg data of deep brain stimulation |
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