Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections

Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections

<p>Parasitic filarial nematodes cause debilitating infections in people in resource-limited countries. A clinically validated approach to eliminating worms uses a 4- to 6-week course of doxycycline that targets <em>Wolbachia</em>, a bacterial endosymbiont required for worm viabilit...

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Main Authors: Bakowski, MA, Shiroodi, RK, Liu, R, Olejniczak, J, Yang, B, Gagaring, K, Guo, H, White, PM, Chappell, L, Debec, A, Landmann, F, Dubben, B, Lenz, F, Struever, D, Ehrens, A, Frohberger, SJ, Sjoberg, H, Pionnier, N, Murphy, E, Archer, J, Steven, A, Chunda, VC, Fombad, FF, Chounna, PW, Njouendou, AJ, Metuge, HM, Ndzeshang, BL, Gandjui, NV, Akumtoh, DN, Kwenti, TDB, Woods, AK, Joseph, SB, Hull, MV, Xiong, W, Kuhen, KL, Taylor, MJ, Wanji, S, Turner, JD, Hübner, MP, Hoerauf, A, Chatterjee, AK, Roland, J, Tremblay, MS, Schultz, PG, Sullivan, W, Chu, X-J, Petrassi, HM, McNamara, CW
Format: Journal article
Language:English
Published: American Association for the Advancement of Science 2019

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