Whole-cell cAMP and PKA activity are epiphenomena, nanodomain signaling matters
Novel targeted fluorescent biosensors provide key insights into very local nanodomains of cAMP and PKA activity, and how they respond differently to β-adrenergic activation in cardiac myocytes. This unique spatiotemporal detail in living cells is not available with biochemical measurements of total...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Physiological Society
2019
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| _version_ | 1797068144996515840 |
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| author | Bers, DM Xiang, YK Zaccolo, M |
| author_facet | Bers, DM Xiang, YK Zaccolo, M |
| author_sort | Bers, DM |
| collection | OXFORD |
| description | Novel targeted fluorescent biosensors provide key insights into very local nanodomains of cAMP and PKA activity, and how they respond differently to β-adrenergic activation in cardiac myocytes. This unique spatiotemporal detail in living cells is not available with biochemical measurements of total cellular cAMP and PKA, and provides unique physiological insights. |
| first_indexed | 2024-03-06T22:06:28Z |
| format | Journal article |
| id | oxford-uuid:50540f4d-e868-4179-a99f-1ca40162f9f6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:06:28Z |
| publishDate | 2019 |
| publisher | American Physiological Society |
| record_format | dspace |
| spelling | oxford-uuid:50540f4d-e868-4179-a99f-1ca40162f9f62022-03-26T16:12:54ZWhole-cell cAMP and PKA activity are epiphenomena, nanodomain signaling mattersJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:50540f4d-e868-4179-a99f-1ca40162f9f6EnglishSymplectic Elements at OxfordAmerican Physiological Society2019Bers, DMXiang, YKZaccolo, MNovel targeted fluorescent biosensors provide key insights into very local nanodomains of cAMP and PKA activity, and how they respond differently to β-adrenergic activation in cardiac myocytes. This unique spatiotemporal detail in living cells is not available with biochemical measurements of total cellular cAMP and PKA, and provides unique physiological insights. |
| spellingShingle | Bers, DM Xiang, YK Zaccolo, M Whole-cell cAMP and PKA activity are epiphenomena, nanodomain signaling matters |
| title | Whole-cell cAMP and PKA activity are epiphenomena, nanodomain signaling matters |
| title_full | Whole-cell cAMP and PKA activity are epiphenomena, nanodomain signaling matters |
| title_fullStr | Whole-cell cAMP and PKA activity are epiphenomena, nanodomain signaling matters |
| title_full_unstemmed | Whole-cell cAMP and PKA activity are epiphenomena, nanodomain signaling matters |
| title_short | Whole-cell cAMP and PKA activity are epiphenomena, nanodomain signaling matters |
| title_sort | whole cell camp and pka activity are epiphenomena nanodomain signaling matters |
| work_keys_str_mv | AT bersdm wholecellcampandpkaactivityareepiphenomenananodomainsignalingmatters AT xiangyk wholecellcampandpkaactivityareepiphenomenananodomainsignalingmatters AT zaccolom wholecellcampandpkaactivityareepiphenomenananodomainsignalingmatters |