Specific interactions between host and parasite genotypes do not act as a constraint on the evolution of antiviral resistance in drosophila
Genetic correlations between parasite resistance and other traits can act as an evolutionary constraint and prevent a population from evolving increased resistance. For example, previous studies have found negative genetic correlations between host resistance and life-history traits. In invertebrate...
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2012
|
| _version_ | 1797068158932090880 |
|---|---|
| author | Carpenter, J Hadfield, J Bangham, J Jiggins, F |
| author_facet | Carpenter, J Hadfield, J Bangham, J Jiggins, F |
| author_sort | Carpenter, J |
| collection | OXFORD |
| description | Genetic correlations between parasite resistance and other traits can act as an evolutionary constraint and prevent a population from evolving increased resistance. For example, previous studies have found negative genetic correlations between host resistance and life-history traits. In invertebrates, the level of resistance often depends on the combination of the host and parasite genotypes, and in this study, we have investigated whether such specific resistance also acts as an evolutionary constraint. We measured the resistance of different genotypes of the fruit fly Drosophila melanogaster to different genotypes of a naturally occurring pathogen, the sigma virus. Using a multitrait analysis, we examine whether genetic covariances alter the potential to select for general resistance against all of the different viral genotypes. We found large amounts of heritable variation in resistance, and evidence for specific interactions between host and parasite, but these interactions resulted in little constraint on Drosophila evolving greater resistance. © 2011 The Author(s). Evolution © 2011 The Society for the Study of Evolution. |
| first_indexed | 2024-03-06T22:06:40Z |
| format | Journal article |
| id | oxford-uuid:5067cdb7-2d06-4247-87e1-8dacf90db2e2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:06:40Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:5067cdb7-2d06-4247-87e1-8dacf90db2e22022-03-26T16:13:17ZSpecific interactions between host and parasite genotypes do not act as a constraint on the evolution of antiviral resistance in drosophilaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5067cdb7-2d06-4247-87e1-8dacf90db2e2EnglishSymplectic Elements at Oxford2012Carpenter, JHadfield, JBangham, JJiggins, FGenetic correlations between parasite resistance and other traits can act as an evolutionary constraint and prevent a population from evolving increased resistance. For example, previous studies have found negative genetic correlations between host resistance and life-history traits. In invertebrates, the level of resistance often depends on the combination of the host and parasite genotypes, and in this study, we have investigated whether such specific resistance also acts as an evolutionary constraint. We measured the resistance of different genotypes of the fruit fly Drosophila melanogaster to different genotypes of a naturally occurring pathogen, the sigma virus. Using a multitrait analysis, we examine whether genetic covariances alter the potential to select for general resistance against all of the different viral genotypes. We found large amounts of heritable variation in resistance, and evidence for specific interactions between host and parasite, but these interactions resulted in little constraint on Drosophila evolving greater resistance. © 2011 The Author(s). Evolution © 2011 The Society for the Study of Evolution. |
| spellingShingle | Carpenter, J Hadfield, J Bangham, J Jiggins, F Specific interactions between host and parasite genotypes do not act as a constraint on the evolution of antiviral resistance in drosophila |
| title | Specific interactions between host and parasite genotypes do not act as a constraint on the evolution of antiviral resistance in drosophila |
| title_full | Specific interactions between host and parasite genotypes do not act as a constraint on the evolution of antiviral resistance in drosophila |
| title_fullStr | Specific interactions between host and parasite genotypes do not act as a constraint on the evolution of antiviral resistance in drosophila |
| title_full_unstemmed | Specific interactions between host and parasite genotypes do not act as a constraint on the evolution of antiviral resistance in drosophila |
| title_short | Specific interactions between host and parasite genotypes do not act as a constraint on the evolution of antiviral resistance in drosophila |
| title_sort | specific interactions between host and parasite genotypes do not act as a constraint on the evolution of antiviral resistance in drosophila |
| work_keys_str_mv | AT carpenterj specificinteractionsbetweenhostandparasitegenotypesdonotactasaconstraintontheevolutionofantiviralresistanceindrosophila AT hadfieldj specificinteractionsbetweenhostandparasitegenotypesdonotactasaconstraintontheevolutionofantiviralresistanceindrosophila AT banghamj specificinteractionsbetweenhostandparasitegenotypesdonotactasaconstraintontheevolutionofantiviralresistanceindrosophila AT jigginsf specificinteractionsbetweenhostandparasitegenotypesdonotactasaconstraintontheevolutionofantiviralresistanceindrosophila |