A G1‐like state allows HIV‐1 to bypass SAMHD1 restriction in macrophages

A G1‐like state allows HIV‐1 to bypass SAMHD1 restriction in macrophages

An unresolved question is how HIV‐1 achieves efficient replication in terminally differentiated macrophages despite the restriction factor SAMHD1. We reveal inducible changes in expression of cell cycle‐associated proteins including MCM2 and cyclins A, E, D1/D3 in macrophages, without evidence for D...

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Bibliographic Details
Main Authors: Mlcochova, P, Sutherland, KA, Watters, SA, Bertoli, C, de Bruin, RA, Rehwinkel, J, Neil, SJ, Lenzi, GM, Kim, B, Khwaja, A, Gage, MC, Georgiou, C, Chittka, A, Yona, S, Noursadeghi, M, Towers, GJ, Gupta, RK
Format: Journal article
Language:English
Published: EMBO Press 2017

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