Hypoxia-inducible factor is expressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte-osteoclast differentiation via induction of VEGF
Hypoxia is an important regulator of bone biology and stimulates osteoclast differentiation from monocytic precursors. Hypoxia-inducible factor (HIF) is a key pro-tumourigenic transcription factor mediating pathways of hypoxia-inducible gene expression. We have described expression of HIF-1α and HIF...
Main Authors: | Knowles, H, Athanasou, N |
---|---|
Format: | Journal article |
Language: | English |
Published: |
John Wiley & Sons, Ltd.
2008
|
Subjects: |
Similar Items
-
Heterogeneity of tumour response to hypoxia: carbonic anhydrase IX induction defines a subpopulation of hypoxic cells with stem cell properties and drug resistance
by: Ledaki, I
Published: (2013) -
The role of p53 in hypoxia-induced apoptosis
by: Poole, R
Published: (2010) -
Functional analysis of cancer/testis antigens in human cancer
by: Pagotto, A
Published: (2013) -
Mitochondrial modulators of hypoxia-related pathways in tumours
by: Snell, CE
Published: (2013) -
The role of ATF4 in hypoxia-induced cell death in cancer
by: Pike, L, et al.
Published: (2011)