Hypoxia-inducible factor is expressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte-osteoclast differentiation via induction of VEGF

Hypoxia-inducible factor is expressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte-osteoclast differentiation via induction of VEGF

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Hypoxia is an important regulator of bone biology and stimulates osteoclast differentiation from monocytic precursors. Hypoxia-inducible factor (HIF) is a key pro-tumourigenic transcription factor mediating pathways of hypoxia-inducible gene expression. We have described expression of HIF-1α and HIF...

Полное описание

Библиографические подробности
Главные авторы:	Knowles, H, Athanasou, N
Формат:	Journal article
Язык:	English
Опубликовано:	John Wiley & Sons, Ltd. 2008
Предметы:	Biology (medical sciences) Cell Biology (see also Plant sciences) Oncology Tumours Tumour pathology Pathology

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