Hypoxia-inducible factor is expressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte-osteoclast differentiation via induction of VEGF
Hypoxia is an important regulator of bone biology and stimulates osteoclast differentiation from monocytic precursors. Hypoxia-inducible factor (HIF) is a key pro-tumourigenic transcription factor mediating pathways of hypoxia-inducible gene expression. We have described expression of HIF-1α and HIF...
| Автори: | , |
|---|---|
| Формат: | Journal article |
| Мова: | English |
| Опубліковано: |
John Wiley & Sons, Ltd.
2008
|
| Предмети: |