Lysine methylation and the regulation of p53.
The p53 tumour suppressor protein functions as a guardian against genotoxic stress. This function is mediated in part by the transcriptional activation of genes involved in cell-cycle arrest, apoptosis, DNA repair and autophagy. The activity of p53 is regulated by a complex array of post-translation...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2012
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| _version_ | 1826272123389214720 |
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| author | Carr, S Munro, S La Thangue, N |
| author_facet | Carr, S Munro, S La Thangue, N |
| author_sort | Carr, S |
| collection | OXFORD |
| description | The p53 tumour suppressor protein functions as a guardian against genotoxic stress. This function is mediated in part by the transcriptional activation of genes involved in cell-cycle arrest, apoptosis, DNA repair and autophagy. The activity of p53 is regulated by a complex array of post-translational modifications, which function as a code to determine cellular responses to a given stress. In this chapter we highlight recent advances in our understanding of this code, with particular reference to lysine methylation, and discuss implications for future research. |
| first_indexed | 2024-03-06T22:07:34Z |
| format | Journal article |
| id | oxford-uuid:50ab790d-9dec-4307-848b-0cc116d0ee20 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:07:34Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:50ab790d-9dec-4307-848b-0cc116d0ee202022-03-26T16:14:59ZLysine methylation and the regulation of p53.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:50ab790d-9dec-4307-848b-0cc116d0ee20EnglishSymplectic Elements at Oxford2012Carr, SMunro, SLa Thangue, NThe p53 tumour suppressor protein functions as a guardian against genotoxic stress. This function is mediated in part by the transcriptional activation of genes involved in cell-cycle arrest, apoptosis, DNA repair and autophagy. The activity of p53 is regulated by a complex array of post-translational modifications, which function as a code to determine cellular responses to a given stress. In this chapter we highlight recent advances in our understanding of this code, with particular reference to lysine methylation, and discuss implications for future research. |
| spellingShingle | Carr, S Munro, S La Thangue, N Lysine methylation and the regulation of p53. |
| title | Lysine methylation and the regulation of p53. |
| title_full | Lysine methylation and the regulation of p53. |
| title_fullStr | Lysine methylation and the regulation of p53. |
| title_full_unstemmed | Lysine methylation and the regulation of p53. |
| title_short | Lysine methylation and the regulation of p53. |
| title_sort | lysine methylation and the regulation of p53 |
| work_keys_str_mv | AT carrs lysinemethylationandtheregulationofp53 AT munros lysinemethylationandtheregulationofp53 AT lathanguen lysinemethylationandtheregulationofp53 |