Cancer immunotherapy: Killers on sterols.
The dream of stimulating the body's immune response to fight cancer has become a reality in the past decade. Several potent drugs have been clinically approved that block inhibitory checkpoints in the immune system, boosting the ability of the system's T cells to mount responses against a...
| Main Author: | |
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| Format: | Journal article |
| Language: | English |
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Nature Publishing Group
2016
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| _version_ | 1797068241878646784 |
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| author | Dustin, M |
| author_facet | Dustin, M |
| author_sort | Dustin, M |
| collection | OXFORD |
| description | The dream of stimulating the body's immune response to fight cancer has become a reality in the past decade. Several potent drugs have been clinically approved that block inhibitory checkpoints in the immune system, boosting the ability of the system's T cells to mount responses against a range of cancers1. Furthermore, patients' own T cells have been successfully genetically engineered to attack blood-cancer cells2. Although these studies have established the immune system as a powerful ally in cancer therapy, there are still many challenges to overcome, and further advances would increase the number of people who stand to benefit from immunotherapy. In this issue, Yang and colleagues3 (page 651) propose a way to boost the function of antitumour T cells, using a metabolic trick to increase the level of cholesterol in the cells' membranes. |
| first_indexed | 2024-03-06T22:07:53Z |
| format | Journal article |
| id | oxford-uuid:50c816e6-e9db-46e7-a236-0fac419fc271 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:07:53Z |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:50c816e6-e9db-46e7-a236-0fac419fc2712022-03-26T16:15:33ZCancer immunotherapy: Killers on sterols.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:50c816e6-e9db-46e7-a236-0fac419fc271EnglishSymplectic Elements at OxfordNature Publishing Group2016Dustin, MThe dream of stimulating the body's immune response to fight cancer has become a reality in the past decade. Several potent drugs have been clinically approved that block inhibitory checkpoints in the immune system, boosting the ability of the system's T cells to mount responses against a range of cancers1. Furthermore, patients' own T cells have been successfully genetically engineered to attack blood-cancer cells2. Although these studies have established the immune system as a powerful ally in cancer therapy, there are still many challenges to overcome, and further advances would increase the number of people who stand to benefit from immunotherapy. In this issue, Yang and colleagues3 (page 651) propose a way to boost the function of antitumour T cells, using a metabolic trick to increase the level of cholesterol in the cells' membranes. |
| spellingShingle | Dustin, M Cancer immunotherapy: Killers on sterols. |
| title | Cancer immunotherapy: Killers on sterols. |
| title_full | Cancer immunotherapy: Killers on sterols. |
| title_fullStr | Cancer immunotherapy: Killers on sterols. |
| title_full_unstemmed | Cancer immunotherapy: Killers on sterols. |
| title_short | Cancer immunotherapy: Killers on sterols. |
| title_sort | cancer immunotherapy killers on sterols |
| work_keys_str_mv | AT dustinm cancerimmunotherapykillersonsterols |