CD4 intragenic SNPs associate with HIV-2 plasma viral load and CD4 count in a community-based study from Guinea-Bissau, West Africa.
OBJECTIVES: The human genetics of HIV-2 infection and disease progression is understudied. Therefore, we studied the effect of variation in 2 genes that encode products critical to HIV pathogenesis and disease progression: CD4 and CD209. DESIGN: This cross-sectional study consisted of 143 HIV-2, 30...
| Hlavní autoři: | , , , , , , , , , , , , , , |
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| Médium: | Journal article |
| Jazyk: | English |
| Vydáno: |
2011
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| _version_ | 1826272155530166272 |
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| author | Hennig, B Velez-Edwards, DR Schim van der Loeff, M Bisseye, C Edwards, T Tacconelli, A Novelli, G Aaby, P Kaye, S Scott, W Jaye, A Whittle, H Williams, S Hill, A Sirugo, G |
| author_facet | Hennig, B Velez-Edwards, DR Schim van der Loeff, M Bisseye, C Edwards, T Tacconelli, A Novelli, G Aaby, P Kaye, S Scott, W Jaye, A Whittle, H Williams, S Hill, A Sirugo, G |
| author_sort | Hennig, B |
| collection | OXFORD |
| description | OBJECTIVES: The human genetics of HIV-2 infection and disease progression is understudied. Therefore, we studied the effect of variation in 2 genes that encode products critical to HIV pathogenesis and disease progression: CD4 and CD209. DESIGN: This cross-sectional study consisted of 143 HIV-2, 30 HIV-1 + HIV-2 and 29 HIV-1-infected subjects and 194 uninfected controls recruited from rural Guinea-Bissau. METHODS: We genotyped 14 CD4 and 4 CD209 single nucleotide polymorphisms (SNPs) that were tested for association with HIV infection, HIV-2 plasma viral load (high vs. low), and CD4 T-cell count (high vs. low). RESULTS: The most significant association was between a CD4 haplotype rs11575097-rs10849523 and high viral load [odds ratio (OR): = 2.37, 95% confidence interval (CI): 1.35 to 4.19, P = 0.001, corrected for multiple testing], suggesting increased genetic susceptibility to HIV-2 disease progression for individuals carrying the high-risk haplotype. Significant associations were also observed at a CD4 SNP (rs2255301) with HIV-2 infection (OR: = 2.36, 95% CI: 1.19 to 4.65, P = 0.01) and any HIV infection (OR: = 2.50, 95% CI: 1.34 to 4.69, P = 0.004). CONCLUSIONS: Our results support a role of CD4 polymorphisms in HIV-2 infection, in agreement with recent data showing that CD4 gene variants increase risk to HIV-1 in Kenyan female sex workers. These findings indicate at least some commonality in HIV-1 and HIV-2 susceptibility. |
| first_indexed | 2024-03-06T22:08:04Z |
| format | Journal article |
| id | oxford-uuid:50d70a60-c0da-487c-a38c-a541de6fba4a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:08:04Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:50d70a60-c0da-487c-a38c-a541de6fba4a2022-03-26T16:16:05ZCD4 intragenic SNPs associate with HIV-2 plasma viral load and CD4 count in a community-based study from Guinea-Bissau, West Africa.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:50d70a60-c0da-487c-a38c-a541de6fba4aEnglishSymplectic Elements at Oxford2011Hennig, BVelez-Edwards, DRSchim van der Loeff, MBisseye, CEdwards, TTacconelli, ANovelli, GAaby, PKaye, SScott, WJaye, AWhittle, HWilliams, SHill, ASirugo, GOBJECTIVES: The human genetics of HIV-2 infection and disease progression is understudied. Therefore, we studied the effect of variation in 2 genes that encode products critical to HIV pathogenesis and disease progression: CD4 and CD209. DESIGN: This cross-sectional study consisted of 143 HIV-2, 30 HIV-1 + HIV-2 and 29 HIV-1-infected subjects and 194 uninfected controls recruited from rural Guinea-Bissau. METHODS: We genotyped 14 CD4 and 4 CD209 single nucleotide polymorphisms (SNPs) that were tested for association with HIV infection, HIV-2 plasma viral load (high vs. low), and CD4 T-cell count (high vs. low). RESULTS: The most significant association was between a CD4 haplotype rs11575097-rs10849523 and high viral load [odds ratio (OR): = 2.37, 95% confidence interval (CI): 1.35 to 4.19, P = 0.001, corrected for multiple testing], suggesting increased genetic susceptibility to HIV-2 disease progression for individuals carrying the high-risk haplotype. Significant associations were also observed at a CD4 SNP (rs2255301) with HIV-2 infection (OR: = 2.36, 95% CI: 1.19 to 4.65, P = 0.01) and any HIV infection (OR: = 2.50, 95% CI: 1.34 to 4.69, P = 0.004). CONCLUSIONS: Our results support a role of CD4 polymorphisms in HIV-2 infection, in agreement with recent data showing that CD4 gene variants increase risk to HIV-1 in Kenyan female sex workers. These findings indicate at least some commonality in HIV-1 and HIV-2 susceptibility. |
| spellingShingle | Hennig, B Velez-Edwards, DR Schim van der Loeff, M Bisseye, C Edwards, T Tacconelli, A Novelli, G Aaby, P Kaye, S Scott, W Jaye, A Whittle, H Williams, S Hill, A Sirugo, G CD4 intragenic SNPs associate with HIV-2 plasma viral load and CD4 count in a community-based study from Guinea-Bissau, West Africa. |
| title | CD4 intragenic SNPs associate with HIV-2 plasma viral load and CD4 count in a community-based study from Guinea-Bissau, West Africa. |
| title_full | CD4 intragenic SNPs associate with HIV-2 plasma viral load and CD4 count in a community-based study from Guinea-Bissau, West Africa. |
| title_fullStr | CD4 intragenic SNPs associate with HIV-2 plasma viral load and CD4 count in a community-based study from Guinea-Bissau, West Africa. |
| title_full_unstemmed | CD4 intragenic SNPs associate with HIV-2 plasma viral load and CD4 count in a community-based study from Guinea-Bissau, West Africa. |
| title_short | CD4 intragenic SNPs associate with HIV-2 plasma viral load and CD4 count in a community-based study from Guinea-Bissau, West Africa. |
| title_sort | cd4 intragenic snps associate with hiv 2 plasma viral load and cd4 count in a community based study from guinea bissau west africa |
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