Extracellular calreticulin is present in the joints of patients with rheumatoid arthritis and inhibits FasL (CD95L)-mediated apoptosis of T cells.
OBJECTIVE: The binding of FasL (CD95L) to its receptor, Fas (CD95), induces apoptosis. Studies have shown that in patients with rheumatoid arthritis (RA), T lymphocytes are resistant to FasL-induced apoptosis in vivo but are susceptible to FasL-induced apoptosis in vitro. Dysfunction in this mechan...
Hauptverfasser: | Tarr, J, Winyard, P, Ryan, B, Harries, L, Haigh, R, Viner, N, Eggleton, P |
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Format: | Journal article |
Sprache: | English |
Veröffentlicht: |
2010
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