Suramin inhibits osteoarthritic cartilage degradation by increasing extracellular levels of chondroprotective tissue inhibitor of metalloproteinases 3 (TIMP-3)

Suramin inhibits osteoarthritic cartilage degradation by increasing extracellular levels of chondroprotective tissue inhibitor of metalloproteinases 3 (TIMP-3)

Osteoarthritis is a common degenerative joint disease for which no disease-modifying drugs are currently available. Attempts to treat the disease with small molecule inhibitors of the metalloproteinases that degrade the cartilage matrix have been hampered by a lack of specificity. We aimed to inhibi...

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Những tác giả chính:	Chanalaris, A, Doherty, C, Marsden, B, Bambridge, G, Wren, S, Nagase, H, Troeberg, L
Định dạng:	Journal article
Được phát hành:	American Society for Pharmacology and Experimental Therapeutics 2017

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