Suramin inhibits osteoarthritic cartilage degradation by increasing extracellular levels of chondroprotective tissue inhibitor of metalloproteinases 3 (TIMP-3)

Suramin inhibits osteoarthritic cartilage degradation by increasing extracellular levels of chondroprotective tissue inhibitor of metalloproteinases 3 (TIMP-3)

Osteoarthritis is a common degenerative joint disease for which no disease-modifying drugs are currently available. Attempts to treat the disease with small molecule inhibitors of the metalloproteinases that degrade the cartilage matrix have been hampered by a lack of specificity. We aimed to inhibi...

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Bibliografiske detaljer
Main Authors:	Chanalaris, A, Doherty, C, Marsden, B, Bambridge, G, Wren, S, Nagase, H, Troeberg, L
Format:	Journal article
Udgivet:	American Society for Pharmacology and Experimental Therapeutics 2017

Lignende værker

Engineered tissue inhibitor of metalloproteinases-3 variants resistant to endocytosis have prolonged chondroprotective activity
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Udgivet: (2016)

Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage
af: Yang, CY, et al.
Udgivet: (2020)

Fibronectin fragments induce aggrecan degradation in human cartilage and are increased in osteoarthritic cartilage
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Udgivet: (2007)

Calcium pentosan polysulfate is a multi-functional aggrecanase inhibitor that enhances interaction with endogenous TIMP-3 in cartilage
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Udgivet: (2009)

Heparan sulfate proteoglycan synthesis is dysregulated in human osteoarthritic cartilage
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Udgivet: (2018)

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Udgivet: (2002)

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Udgivet: (2006)

LRP-dependent and -independent internalisation of TIMP-3
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Udgivet: (2011)

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Udgivet: (2003)

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Udgivet: (2000)

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Udgivet: (2014)

Sulfated glycosaminoglycans control the extracellular trafficking and the activity of the metalloprotease inhibitor TIMP-3.
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Udgivet: (2014)

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Udgivet: (2012)

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Udgivet: (2016)

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Udgivet: (2007)

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Udgivet: (2018)

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Udgivet: (2012)

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Udgivet: (2004)

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Udgivet: (2010)

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Udgivet: (2009)

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Udgivet: (2004)

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Udgivet: (2015)

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Udgivet: (2003)

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Udgivet: (2003)

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Udgivet: (2006)

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Udgivet: (2018)

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Udgivet: (1995)

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Udgivet: (2009)

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Udgivet: (2003)

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Udgivet: (2009)

ADAMTS and ADAM metalloproteinases in osteoarthritis - looking beyond the ‘usual suspects’
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Udgivet: (2017)

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Udgivet: (2004)

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Udgivet: (2003)

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Udgivet: (1998)

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Udgivet: (1996)

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af: Stinn, Jennifer L. (Jennifer Leigh)
Udgivet: (2007)

3D osteoarthritic model.
af: Ng, Ling Yen.
Udgivet: (2013)

Calcium pentosan polysulfate increases affinity between aggrecanases (ADAMTS-4 and-5) and TIMP-3 by a conformational change
af: Troeberg, L, et al.
Udgivet: (2010)