A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 st...
| Главные авторы: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Формат: | Journal article |
| Язык: | English |
| Опубликовано: |
2010
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| _version_ | 1826272196033511424 |
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| author | Rothman, N Garcia-Closas, M Chatterjee, N Malats, N Wu, X Figueroa, J Real, F Van Den Berg, D Matullo, G Baris, D Thun, M Kiemeney, L Vineis, P De Vivo, I Albanes, D Purdue, M Rafnar, T Hildebrandt, M Kiltie, A Cussenot, O Golka, K Kumar, R Taylor, J Mayordomo, J Jacobs, K |
| author_facet | Rothman, N Garcia-Closas, M Chatterjee, N Malats, N Wu, X Figueroa, J Real, F Van Den Berg, D Matullo, G Baris, D Thun, M Kiemeney, L Vineis, P De Vivo, I Albanes, D Purdue, M Rafnar, T Hildebrandt, M Kiltie, A Cussenot, O Golka, K Kumar, R Taylor, J Mayordomo, J Jacobs, K |
| author_sort | Rothman, N |
| collection | OXFORD |
| description | We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis. |
| first_indexed | 2024-03-06T22:08:42Z |
| format | Journal article |
| id | oxford-uuid:510f54f8-d3e0-486f-8f4a-a46fe7a7f452 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:08:42Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:510f54f8-d3e0-486f-8f4a-a46fe7a7f4522022-03-26T16:17:14ZA multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:510f54f8-d3e0-486f-8f4a-a46fe7a7f452EnglishSymplectic Elements at Oxford2010Rothman, NGarcia-Closas, MChatterjee, NMalats, NWu, XFigueroa, JReal, FVan Den Berg, DMatullo, GBaris, DThun, MKiemeney, LVineis, PDe Vivo, IAlbanes, DPurdue, MRafnar, THildebrandt, MKiltie, ACussenot, OGolka, KKumar, RTaylor, JMayordomo, JJacobs, KWe conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis. |
| spellingShingle | Rothman, N Garcia-Closas, M Chatterjee, N Malats, N Wu, X Figueroa, J Real, F Van Den Berg, D Matullo, G Baris, D Thun, M Kiemeney, L Vineis, P De Vivo, I Albanes, D Purdue, M Rafnar, T Hildebrandt, M Kiltie, A Cussenot, O Golka, K Kumar, R Taylor, J Mayordomo, J Jacobs, K A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. |
| title | A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. |
| title_full | A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. |
| title_fullStr | A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. |
| title_full_unstemmed | A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. |
| title_short | A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. |
| title_sort | multi stage genome wide association study of bladder cancer identifies multiple susceptibility loci |
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