In vivo alterations in cardiac metabolism and function in the spontaneously hypertensive rat heart.

In vivo alterations in cardiac metabolism and function in the spontaneously hypertensive rat heart.

AIMS: The aim of this work was to use hyperpolarized carbon-13 ((13)C) magnetic resonance (MR) spectroscopy and cine MR imaging (MRI) to assess in vivo cardiac metabolism and function in the 15-week-old spontaneously hypertensive rat (SHR) heart. At this time point, the SHR displays hypertension and...

Full description

Bibliographic Details
Main Authors:	Dodd, M, Ball, DR, Schroeder, M, Le Page, L, Atherton, H, Heather, L, Seymour, A, Ashrafian, H, Watkins, H, Clarke, K, Tyler, D
Format:	Journal article
Language:	English
Published:	2012

Similar Items

In vivo mouse cardiac hyperpolarized magnetic resonance spectroscopy.
by: Dodd, M, et al.
Published: (2013)

Simultaneous in vivo assessment of cardiac and hepatic metabolism in the diabetic rat using hyperpolarized MRS
by: Le Page, L, et al.
Published: (2016)

Determining the in vivo regulation of cardiac pyruvate dehydrogenase based on label flux from hyperpolarised [1-13C]pyruvate.
by: Schroeder, M, et al.
Published: (2011)

Real Time, in vivo Observation of Oxidative Carbohydrate Metabolism Reveals the Key Regulatory Role of Acetyl-Carnitine as a Substrate Buffer in the Heart
by: Schroeder, M, et al.
Published: (2009)

Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised 13C MRS.
by: Atherton, H, et al.
Published: (2011)

INVESTIGATING METABOLIC FLUX IN THE HYPERTHYROID HEART USING HYPERPOLARISED MAGNETIC RESONANCE
by: Dodd, M, et al.
Published: (2010)

The cycling of acetyl-coenzyme A through acetylcarnitine buffers cardiac substrate supply: a hyperpolarized 13C magnetic resonance study.
by: Schroeder, M, et al.
Published: (2012)

Assessment of real-time in vivo cardiac and hepatic glucose metabolism in the diabetic rat, using hyperpolarised C-13 pyruvate
by: Le Page, L, et al.
Published: (2013)

Role of pyruvate dehydrogenase inhibition in the development of hypertrophy in the hyperthyroid rat heart: a combined magnetic resonance imaging and hyperpolarized magnetic resonance spectroscopy study.
by: Atherton, H, et al.
Published: (2011)

Investigating Metabolic Flux in the Hyperthyroid Heart using Hyperpolarised Magnetic Resonance
by: Atherton, H, et al.
Published: (2008)

Determination of cardiac metabolism in vivo with hyperpolarized carbon-13 magnetic resonance
by: Schroeder, M, et al.
Published: (2007)

IMPAIRED IN VIVO MITOCHONDRIAL KREBS CYCLE ACTIVITY FOLLOWING MYOCARDIAL INFARCTION ASSESSED USING HYPERPOLARIZED MAGNETIC RESONANCE SPECTROSCOPY
by: Dodd, M, et al.
Published: (2013)

REAL-TIME ASSESSMENT OF KREBS CYCLE METABOLISM WITH HYPERPOLARISED [2-13C]PYRUVATE
by: Atherton, H, et al.
Published: (2010)

The von Hippel-Lindau Chuvash mutation in mice alters cardiac substrate and high energy phosphate metabolism
by: Slingo, M, et al.
Published: (2016)

Alterations of Lipid Metabolism in the Heart in Spontaneously Hypertensive Rats Precedes Left Ventricular Hypertrophy and Cardiac Dysfunction
by: Tomasz K. Bednarski, et al.
Published: (2022-09-01)

Impaired in vivo mitochondrial Krebs cycle activity after myocardial infarction assessed using hyperpolarized magnetic resonance spectroscopy.
by: Dodd, M, et al.
Published: (2014)

In vivo cardiac 1H-MRS in the mouse.
by: Schneider, J, et al.
Published: (2004)

Use of Hyperpolarized Magnetic Resonance for Non-Invasive Observation of Metabolic Regulation
by: Schroeder, M, et al.
Published: (2008)

In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance.
by: Schroeder, M, et al.
Published: (2008)

Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy.
by: Schroeder, M, et al.
Published: (2009)

Cardiac energetics in congestive heart failure.
by: Ashrafian, H
Published: (2002)

Evidence for increased in vivo Na(+)-H+ antiporter activity and an altered skeletal muscle contractile response in the spontaneously hypertensive rat.
by: Syme, P, et al.
Published: (1990)

The role of adenosine A2A receptor signalling in cardiac fibrosis
by: Stockenhuber, A, et al.
Published: (2015)

Peripheral Cardiac Sympathetic dysfunction in the pre-hypertensive Spontaneously Hypertensive Rat
by: Shanks, J, et al.
Published: (2012)

Peripheral Cardiac Sympathetic dysfunction in the pre-hypertensive Spontaneously Hypertensive Rat
by: Shanks, J, et al.
Published: (2010)

CHRONIC HYPOXIA CAUSES NO CHANGE IN CARDIAC PYRUVATE DEHYDROGENASE FLUX IN THE CONTROL OR DIABETIC RAT: AN IN VIVO STUDY
by: Le Page, L, et al.
Published: (2013)

Progressive Cardiac Metabolic Defects Accompany Diastolic and Severe Systolic Dysfunction in Spontaneously Hypertensive Rat Hearts
by: Jie Li, et al.
Published: (2023-05-01)

Modulation of cardiac energetics as a target in ischemic heart disease
by: Ashrafian, H
Published: (2011)

Hyperpolarized butyrate: a metabolic probe of short chain fatty acid metabolism in the heart.
by: Ball, DR, et al.
Published: (2014)

Cardiac sympathetic dysfunction in the prehypertensive spontaneously hypertensive rat
by: Shanks, J, et al.
Published: (2013)

The effect of hyperpolarized tracer concentration on myocardial uptake and metabolism.
by: Schroeder, M, et al.
Published: (2009)

Metformin Improves Cardiac Metabolism and Function, and Prevents Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats
by: Jie Li, et al.
Published: (2020-04-01)

Genetic cardiomyopathies causing heart failure.
by: Cahill, T, et al.
Published: (2013)

AMP-Activated Protein Kinase Phosphorylates Cardiac Troponin I and Alters Contractility of Murine Ventricular Myocytes
by: Oliveira, S, et al.
Published: (2012)

AMP-Activated protein kinase phosphorylates cardiac troponin i and alters contractility of murine ventricular myocytes
by: Oliveira, S, et al.
Published: (2012)

AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes.
by: Oliveira, S, et al.
Published: (2012)

Application of hyperpolarized magnetic resonance in the study of cardiac metabolism
by: Tyler, D, et al.
Published: (2008)

Differential translocation of the fatty acid transporter, FAT/CD36, and the glucose transporter, GLUT4, coordinates changes in cardiac substrate metabolism during ischemia and reperfusion.
by: Heather, L, et al.
Published: (2013)

Sex- and age-related differences in renal and cardiac injury and senescence in stroke-prone spontaneously hypertensive rats
by: Aneesa Ansari, et al.
Published: (2023-05-01)

Pravastatin normalises peripheral cardiac sympathetic hyperactivity in the spontaneously hypertensive rat
by: Herring, N, et al.
Published: (2010)