Oligomerization of the human prion protein proceeds via a molten globule intermediate.

Oligomerization of the human prion protein proceeds via a molten globule intermediate.

The conformational transition of the human prion protein from an alpha-helical to a beta-sheet-rich structure is believed to be the critical event in prion pathogenesis. The molecular mechanism of misfolding and the role of intermediate states during this transition remain poorly understood. To over...

Полное описание

Библиографические подробности
Главные авторы:	Gerber, R, Tahiri-Alaoui, A, Hore, P, James, W
Формат:	Journal article
Язык:	English
Опубликовано:	2007

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