Self-organizing & stochastic behaviors during the regeneration of hair stem cells
Stem cells cycle through active and quiescent states. Large populations of stem cells in an organ may cycle randomly or in a coordinated manner. Although stem cell cycling within single hair follicles has been studied, less is known about regenerative behavior in a hair follicle population. By combi...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
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Science
2011
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| _version_ | 1797068354892070912 |
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| author | Plikus, M Baker, R Chen, C Fare, C de La Cruz, D Andl, T Maini, P |
| author_facet | Plikus, M Baker, R Chen, C Fare, C de La Cruz, D Andl, T Maini, P |
| author_sort | Plikus, M |
| collection | OXFORD |
| description | Stem cells cycle through active and quiescent states. Large populations of stem cells in an organ may cycle randomly or in a coordinated manner. Although stem cell cycling within single hair follicles has been studied, less is known about regenerative behavior in a hair follicle population. By combining predictive mathematical modeling with in vivo studies in mice and rabbits, we show that a follicle progresses through cycling stages by continuous integration of inputs from intrinsic follicular and extrinsic environmental signals based on universal patterning principles. Signaling from the WNT/bone morphogenetic protein activator/inhibitor pair is coopted to mediate interactions among follicles in the population. This regenerative strategy is robust and versatile because relative activator/inhibitor strengths can be modulated easily, adapting the organism to different physiological and evolutionary needs. |
| first_indexed | 2024-03-06T22:09:34Z |
| format | Journal article |
| id | oxford-uuid:515709f8-dd1b-44a6-8dcc-62eead6b7676 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T22:09:34Z |
| publishDate | 2011 |
| publisher | Science |
| record_format | dspace |
| spelling | oxford-uuid:515709f8-dd1b-44a6-8dcc-62eead6b76762022-03-26T16:19:01ZSelf-organizing & stochastic behaviors during the regeneration of hair stem cellsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:515709f8-dd1b-44a6-8dcc-62eead6b7676Mathematical Institute - ePrintsScience2011Plikus, MBaker, RChen, CFare, Cde La Cruz, DAndl, TMaini, PStem cells cycle through active and quiescent states. Large populations of stem cells in an organ may cycle randomly or in a coordinated manner. Although stem cell cycling within single hair follicles has been studied, less is known about regenerative behavior in a hair follicle population. By combining predictive mathematical modeling with in vivo studies in mice and rabbits, we show that a follicle progresses through cycling stages by continuous integration of inputs from intrinsic follicular and extrinsic environmental signals based on universal patterning principles. Signaling from the WNT/bone morphogenetic protein activator/inhibitor pair is coopted to mediate interactions among follicles in the population. This regenerative strategy is robust and versatile because relative activator/inhibitor strengths can be modulated easily, adapting the organism to different physiological and evolutionary needs. |
| spellingShingle | Plikus, M Baker, R Chen, C Fare, C de La Cruz, D Andl, T Maini, P Self-organizing & stochastic behaviors during the regeneration of hair stem cells |
| title | Self-organizing & stochastic behaviors during the regeneration of hair stem cells |
| title_full | Self-organizing & stochastic behaviors during the regeneration of hair stem cells |
| title_fullStr | Self-organizing & stochastic behaviors during the regeneration of hair stem cells |
| title_full_unstemmed | Self-organizing & stochastic behaviors during the regeneration of hair stem cells |
| title_short | Self-organizing & stochastic behaviors during the regeneration of hair stem cells |
| title_sort | self organizing amp stochastic behaviors during the regeneration of hair stem cells |
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