A common variant in the 3'UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar disorder.

A common variant in the 3'UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar disorder.

Underactivity of the glutamatergic system is an attractive model for the pathophysiology of several major mental illnesses. We previously described a chromosome abnormality disrupting the kainate class ionotropic glutamate receptor gene, GRIK4/KA1, in an individual with schizophrenia and learning di...

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Bibliographic Details
Main Authors: Pickard, B, Knight, H, Hamilton, R, Soares, D, Walker, R, Boyd, J, Machell, J, Maclean, A, McGhee, K, Condie, A, Porteous, D, St Clair, D, Davis, I, Blackwood, D, Muir, W
Format: Journal article
Language:English
Published: 2008

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