A cytotoxic rabbit T-cell line infected with a gamma-herpes virus which expresses CD8 and class II antigens.
A rabbit T-cell line, BJ-610, has been derived from a New Zealand White rabbit infected with Alcelaphine herpes virus-1, which has the characteristics of a lymphokine activated killer (LAK) cell. The surface phenotype of this cell line has been studied by flow cytometry, using a panel of monoclonal...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1992
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| _version_ | 1826272277009793024 |
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| author | Wilkinson, J Galea-Lauri, J Reid, H |
| author_facet | Wilkinson, J Galea-Lauri, J Reid, H |
| author_sort | Wilkinson, J |
| collection | OXFORD |
| description | A rabbit T-cell line, BJ-610, has been derived from a New Zealand White rabbit infected with Alcelaphine herpes virus-1, which has the characteristics of a lymphokine activated killer (LAK) cell. The surface phenotype of this cell line has been studied by flow cytometry, using a panel of monoclonal antibodies (mAb) to rabbit leucocyte surface markers, and compared with that of another rabbit T-cell line, RL-5, transformed with herpes virus ateles. The expression of a number of markers is common to the two lines; these include the rabbit analogues of CD11a/CD18, CD43, CD44 and CD45. Three antigens are expressed on BJ-610 but not RL-5. One of these is recognized by a mAb thought to recognize CD8, while a second is a class II R-DQ molecule. The third antigen is expressed on thymocytes, a subset of T cells, neutrophils and platelets but its molecular nature is unknown. These two cell lines should prove useful in preparing reagents which recognize subsets of rabbit T cells and for studying the mechanism of herpes virus-induced lymphoid cell deregulation. |
| first_indexed | 2024-03-06T22:10:00Z |
| format | Journal article |
| id | oxford-uuid:517a709c-2b0a-4271-a090-e5ea0aaebb4f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:10:00Z |
| publishDate | 1992 |
| record_format | dspace |
| spelling | oxford-uuid:517a709c-2b0a-4271-a090-e5ea0aaebb4f2022-03-26T16:19:47ZA cytotoxic rabbit T-cell line infected with a gamma-herpes virus which expresses CD8 and class II antigens.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:517a709c-2b0a-4271-a090-e5ea0aaebb4fEnglishSymplectic Elements at Oxford1992Wilkinson, JGalea-Lauri, JReid, HA rabbit T-cell line, BJ-610, has been derived from a New Zealand White rabbit infected with Alcelaphine herpes virus-1, which has the characteristics of a lymphokine activated killer (LAK) cell. The surface phenotype of this cell line has been studied by flow cytometry, using a panel of monoclonal antibodies (mAb) to rabbit leucocyte surface markers, and compared with that of another rabbit T-cell line, RL-5, transformed with herpes virus ateles. The expression of a number of markers is common to the two lines; these include the rabbit analogues of CD11a/CD18, CD43, CD44 and CD45. Three antigens are expressed on BJ-610 but not RL-5. One of these is recognized by a mAb thought to recognize CD8, while a second is a class II R-DQ molecule. The third antigen is expressed on thymocytes, a subset of T cells, neutrophils and platelets but its molecular nature is unknown. These two cell lines should prove useful in preparing reagents which recognize subsets of rabbit T cells and for studying the mechanism of herpes virus-induced lymphoid cell deregulation. |
| spellingShingle | Wilkinson, J Galea-Lauri, J Reid, H A cytotoxic rabbit T-cell line infected with a gamma-herpes virus which expresses CD8 and class II antigens. |
| title | A cytotoxic rabbit T-cell line infected with a gamma-herpes virus which expresses CD8 and class II antigens. |
| title_full | A cytotoxic rabbit T-cell line infected with a gamma-herpes virus which expresses CD8 and class II antigens. |
| title_fullStr | A cytotoxic rabbit T-cell line infected with a gamma-herpes virus which expresses CD8 and class II antigens. |
| title_full_unstemmed | A cytotoxic rabbit T-cell line infected with a gamma-herpes virus which expresses CD8 and class II antigens. |
| title_short | A cytotoxic rabbit T-cell line infected with a gamma-herpes virus which expresses CD8 and class II antigens. |
| title_sort | cytotoxic rabbit t cell line infected with a gamma herpes virus which expresses cd8 and class ii antigens |
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