HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.

Hypoxia-inducible factor (HIF) regulates expression of genes involved in adaptation to hypoxia and ischemia. Three prolyl hydroxylases (PHD1-3) underlie oxygen-regulated destruction of HIFalpha chains. We have investigated the organ distribution of the PHDs in the rat, their regulation by hypoxia an...

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Bibliographic Details
Main Authors:	Willam, C, Maxwell, P, Nichols, L, Lygate, C, Tian, Y, Bernhardt, W, Wiesener, M, Ratcliffe, P, Eckardt, K, Pugh, C
Format:	Journal article
Language:	English
Published:	2006

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