Disentangling neocortical alpha/beta and hippocampal theta/gamma oscillations in human episodic memory formation
To form an episodic memory, we must first process a vast amount of sensory information about the to-be-encoded event and then bind these sensory representations together to form a coherent memory trace. While these two cognitive capabilities are thought to have two distinct neural origins, with neoc...
| Main Authors: | , , , |
|---|---|
| 格式: | Journal article |
| 语言: | English |
| 出版: |
Elsevier
2021
|
| _version_ | 1826310800232415232 |
|---|---|
| author | Griffiths, BJ Martín-Buro, MC Staresina, BP Hanslmayr, S |
| author_facet | Griffiths, BJ Martín-Buro, MC Staresina, BP Hanslmayr, S |
| author_sort | Griffiths, BJ |
| collection | OXFORD |
| description | To form an episodic memory, we must first process a vast amount of sensory information about the to-be-encoded event and then bind these sensory representations together to form a coherent memory trace. While these two cognitive capabilities are thought to have two distinct neural origins, with neocortical alpha/beta oscillations supporting information representation and hippocampal theta-gamma phase-amplitude coupling supporting mnemonic binding, evidence for a dissociation between these two neural markers is conspicuously absent. To address this, seventeen human participants completed an associative memory task that first involved processing information about three sequentially-presented stimuli, and then binding these stimuli together into a coherent memory trace, all the while undergoing MEG recordings. We found that decreases in neocortical alpha/beta power during sequence perception, but not mnemonic binding, correlated with enhanced memory performance. Hippocampal theta/gamma phase-amplitude coupling, however, showed the opposite pattern; increases during mnemonic binding (but not sequence perception) correlated with enhanced memory performance. These results demonstrate that memory-related decreases in neocortical alpha/beta power and memory-related increases in hippocampal theta/gamma phase-amplitude coupling arise at distinct stages of the memory formation process. We speculate that this temporal dissociation reflects a functional dissociation in which neocortical alpha/beta oscillations could support the processing of incoming information relevant to the memory, while hippocampal theta-gamma phase-amplitude coupling could support the binding of this information into a coherent memory trace. |
| first_indexed | 2024-03-07T07:57:21Z |
| format | Journal article |
| id | oxford-uuid:51a3a2d9-036a-45db-a4af-5b724e6bafe7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:57:21Z |
| publishDate | 2021 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:51a3a2d9-036a-45db-a4af-5b724e6bafe72023-09-05T12:55:51ZDisentangling neocortical alpha/beta and hippocampal theta/gamma oscillations in human episodic memory formationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:51a3a2d9-036a-45db-a4af-5b724e6bafe7EnglishSymplectic ElementsElsevier2021Griffiths, BJMartín-Buro, MCStaresina, BPHanslmayr, STo form an episodic memory, we must first process a vast amount of sensory information about the to-be-encoded event and then bind these sensory representations together to form a coherent memory trace. While these two cognitive capabilities are thought to have two distinct neural origins, with neocortical alpha/beta oscillations supporting information representation and hippocampal theta-gamma phase-amplitude coupling supporting mnemonic binding, evidence for a dissociation between these two neural markers is conspicuously absent. To address this, seventeen human participants completed an associative memory task that first involved processing information about three sequentially-presented stimuli, and then binding these stimuli together into a coherent memory trace, all the while undergoing MEG recordings. We found that decreases in neocortical alpha/beta power during sequence perception, but not mnemonic binding, correlated with enhanced memory performance. Hippocampal theta/gamma phase-amplitude coupling, however, showed the opposite pattern; increases during mnemonic binding (but not sequence perception) correlated with enhanced memory performance. These results demonstrate that memory-related decreases in neocortical alpha/beta power and memory-related increases in hippocampal theta/gamma phase-amplitude coupling arise at distinct stages of the memory formation process. We speculate that this temporal dissociation reflects a functional dissociation in which neocortical alpha/beta oscillations could support the processing of incoming information relevant to the memory, while hippocampal theta-gamma phase-amplitude coupling could support the binding of this information into a coherent memory trace. |
| spellingShingle | Griffiths, BJ Martín-Buro, MC Staresina, BP Hanslmayr, S Disentangling neocortical alpha/beta and hippocampal theta/gamma oscillations in human episodic memory formation |
| title | Disentangling neocortical alpha/beta and hippocampal theta/gamma oscillations in human episodic memory formation |
| title_full | Disentangling neocortical alpha/beta and hippocampal theta/gamma oscillations in human episodic memory formation |
| title_fullStr | Disentangling neocortical alpha/beta and hippocampal theta/gamma oscillations in human episodic memory formation |
| title_full_unstemmed | Disentangling neocortical alpha/beta and hippocampal theta/gamma oscillations in human episodic memory formation |
| title_short | Disentangling neocortical alpha/beta and hippocampal theta/gamma oscillations in human episodic memory formation |
| title_sort | disentangling neocortical alpha beta and hippocampal theta gamma oscillations in human episodic memory formation |
| work_keys_str_mv | AT griffithsbj disentanglingneocorticalalphabetaandhippocampalthetagammaoscillationsinhumanepisodicmemoryformation AT martinburomc disentanglingneocorticalalphabetaandhippocampalthetagammaoscillationsinhumanepisodicmemoryformation AT staresinabp disentanglingneocorticalalphabetaandhippocampalthetagammaoscillationsinhumanepisodicmemoryformation AT hanslmayrs disentanglingneocorticalalphabetaandhippocampalthetagammaoscillationsinhumanepisodicmemoryformation |