A human arterial transcriptomic signature predicts major adverse cardiac events and identifies novel, redox-related therapeutic targets within the vascular wall

A human arterial transcriptomic signature predicts major adverse cardiac events and identifies novel, redox-related therapeutic targets within the vascular wall

Manylion Llyfryddiaeth
Prif Awduron:	Kotanidis, CP, Lockstone, H, Polkinghorne, M, Badi, I, Akoumianakis, I, Siddique, M, Antonopoulos, A, Evans, T, Farid, S, Srivastava, V, Krasopoulos, G, Sayeed, R, Channon, KM, Antoniades, C
Fformat:	Conference item
Iaith:	English
Cyhoeddwyd:	Oxford University Press 2021

Eitemau Tebyg

A novel human arterial transcriptomic signature associated with major adverse cardiovascular events and oxidative stress
gan: Kotanidis, C, et al.
Cyhoeddwyd: (2021)

Human epicardial adipose tissue-secreted miR-92a-3p regulates myocardial redox state via paracrine signalling: implications for cardiovascular clinical outcomes
gan: Badi, I, et al.
Cyhoeddwyd: (2023)

Effects of canagliflozin on human myocardial redox signalling: clinical implications
gan: Kondo, H, et al.
Cyhoeddwyd: (2021)

Oxidative stress in the myocardium as a novel predictor of long-term outcomes in patients undergoing cardiac surgery
gan: Kotanidis, CP, et al.
Cyhoeddwyd: (2019)

Myocardial redox state predicts 3-year mortality in patients undergoing cardiac surgery: the ox-HVF study
gan: Kotanidis, C, et al.
Cyhoeddwyd: (2019)

A novel arterial redox-specific machine learning-derived radiomic signature of perivascular adipose tissue predicts cardiac mortality from routine CCTA
gan: Kotanidis, CP, et al.
Cyhoeddwyd: (2020)

Role of human epicardial adipose tissue–derived miR-92a-3p in myocardial redox state
gan: Carena, MC, et al.
Cyhoeddwyd: (2023)

Abstract 15072: Lipoprotein(a) regulates vascular redox state and predicts adverse cardiovascular outcomes in coronary artery disease
gan: Polkinghorne, MD, et al.
Cyhoeddwyd: (2023)

Genetic variability of lipoprotein(a) controls vascular inflammation/redox signalling and predicts adverse cardiovascular outcomes in coronary artery disease
gan: Polkinghorne, MD, et al.
Cyhoeddwyd: (2023)

Wnt5a contributes to human atherosclerosis via novel USP17 redox signalling
gan: Akoumianakis, I, et al.
Cyhoeddwyd: (2019)

Direct effects of canagliflozin on human myocardial redox signalling: a novel role for SGLT1 inhibition
gan: Kondo, H, et al.
Cyhoeddwyd: (2020)

Novel direct effects of SGLT2 inhibitor, Canagliflozin, on myocardial redox state in humans
gan: Kondo, H, et al.
Cyhoeddwyd: (2019)

NADPH oxidase activity in internal mammary arteries predicts mortality in patients undergoing coronary bypass surgery
gan: Akoumianakis, I, et al.
Cyhoeddwyd: (2018)

Fat-secreted ceramides regulate vascular redox state and influence outcomes in patients with cardiovascular disease
gan: Akawi, N, et al.
Cyhoeddwyd: (2021)

Targeting redox signaling in the vascular wall: from basic science to clinical practice.
gan: Antoniades, C, et al.
Cyhoeddwyd: (2009)

Novel insights into the role of insulin-like growth factor 1 in the regulation of myocardial redox state in humans
gan: Akoumianakis, I, et al.
Cyhoeddwyd: (2016)

Insulin triggers oxidative stress in the vascular wall of patients with atherosclerosis, independently of systemic insulin resistance: the beneficial role of DPP-IV inhibition
gan: Akoumianakis, I, et al.
Cyhoeddwyd: (2018)

Insulin induces oxidatives stress in the vascular wall of patients with atherosclerosis independently of systemic insulin resistance: the regulatory role of DPP4 inhibition
gan: Akoumianakis, I, et al.
Cyhoeddwyd: (2018)

Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition
gan: Akoumianakis, I, et al.
Cyhoeddwyd: (2020)

Perivascular adipose tissue-derived Wnt5a as a regulator of human vascular disease pathogenesis
gan: Akoumianakis, I, et al.
Cyhoeddwyd: (2018)

Insulin Treatment Induces Oxidative Stress in the Vascular Wall of Patients With Atherosclerosis Independently of Diabetes or Systemic Insulin Resistance: The Protective Role of DPP-IV Inhibition
gan: Akoumianakis, I, et al.
Cyhoeddwyd: (2018)

Impaired vascular redox signalling in the vascular complications of obesity and diabetes mellitus
gan: Akoumianakis, I, et al.
Cyhoeddwyd: (2017)

A NOVEL CROSS-TALK BETWEEN PERIVASCULAR ADIPOSE TISSUE AND THE ARTERIAL WALL CONTROLS REDOX STATE IN HUMAN ATHEROSCLEROSIS
gan: Margaritis, M, et al.
Cyhoeddwyd: (2013)

Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17//RAC1-mediated activation of NADPH oxidases
gan: Akoumianakis, I, et al.
Cyhoeddwyd: (2019)

Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications
gan: Akoumianakis, I, et al.
Cyhoeddwyd: (2022)

A novel cross-talk between perivascular adipose tissue and the arterial wall controls redox state in human atherosclerosis
gan: Margaritis, M, et al.
Cyhoeddwyd: (2013)

Mutual Regulation of Epicardial Adipose Tissue and Myocardial Redox State by PPAR-γ/Adiponectin Signalling
gan: Antonopoulos, A, et al.
Cyhoeddwyd: (2016)

A novel CT-derived radiotranscriptomic signature of perivascular adipose tissue stratifies COVID-19 vascular cytokine burst and predicts in hospital outcomes
gan: Kotanidis, CP, et al.
Cyhoeddwyd: (2020)

Translating the effects of statins: from redox regulation to suppression of vascular wall inflammation.
gan: Antonopoulos, A, et al.
Cyhoeddwyd: (2012)

Novel insights into the effects of insulin-like growth factor 1 and endothelin signalling on vascular redox state in patients with type 2 diabetes
gan: Akoumianakis, I, et al.
Cyhoeddwyd: (2016)

Novel Insights into the Effects of Insulin-like Growth Factor 1 and Endothelin Signalling on Vascular Redox State in Patients with Type 2 Diabetes Mellitus
gan: Akoumianakis, I, et al.
Cyhoeddwyd: (2016)

Selfies in cardiovascular medicine: welcome to a new era of medical diagnostics
gan: Kotanidis, CP, et al.
Cyhoeddwyd: (2020)

Targeting interleukin-1: implications for long-term cardiovascular management following radiotherapy
gan: Kotanidis, CP, et al.
Cyhoeddwyd: (2019)

Perivascular fat attenuation index mapping around the right and left coronary artery independently predict cardiac mortality
gan: Kotanidis, CP, et al.
Cyhoeddwyd: (2020)

D Radiotranscriptomic analysis of perivascular adipose tissue quantifies vascular inflammation in covid-19 from routine CT angiograms: stratification of “new UK variant” Infection and prediction of in-hospital outcomes
gan: Kotanidis, CP, et al.
Cyhoeddwyd: (2021)

Regulation of human vascular redox state in obesity and insulin resistance
gan: Akoumianakis, I
Cyhoeddwyd: (2019)

Blood telomere length predicts clinical outcome after acute myocardial infarction: The role of oxidative stress
gan: Margaritis, M, et al.
Cyhoeddwyd: (2016)

Echocardiographic pre-operative early mitral inflow velocity-to-early diastolic strain rate ratio predicts post-operative paroxysmal atrial fibrillation in patients undergoing CABG surgery
gan: Sangha, G, et al.
Cyhoeddwyd: (2017)

Statins: pleiotropic regulators of cardiovascular redox state.
gan: Antoniades, C, et al.
Cyhoeddwyd: (2014)

Pericoronary fat radiomic profile (FRP) predicts long-term cardiac risk in individuals with calcium score below 100 on coronary computed tomography angiography
gan: Kotanidis, CP, et al.
Cyhoeddwyd: (2020)