trkA, CGRP and IB4 expression in retrogradely labelled cutaneous and visceral primary sensory neurones in the rat.

The pattern of trkA expression in relation to other neurochemical markers (CGRP and IB4) was investigated in primary sensory neurones innervating either the skin or bladder. Retrograde tracing using the fluorescent marker Fast Blue was performed followed by histochemistry. A greater proportion of vi...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Bennett, D, Dmietrieva, N, Priestley, J, Clary, D, McMahon, S
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: 1996
_version_ 1826272311936811008
author Bennett, D
Dmietrieva, N
Priestley, J
Clary, D
McMahon, S
author_facet Bennett, D
Dmietrieva, N
Priestley, J
Clary, D
McMahon, S
author_sort Bennett, D
collection OXFORD
description The pattern of trkA expression in relation to other neurochemical markers (CGRP and IB4) was investigated in primary sensory neurones innervating either the skin or bladder. Retrograde tracing using the fluorescent marker Fast Blue was performed followed by histochemistry. A greater proportion of visceral afferents compared with cutaneous afferents were trkA-immunoreactive (75% and 43%, respectively). CGRP expression correlated with trkA expression in that it was higher in visceral afferents than cutaneous afferents (69% and 51%, respectively). IB4 expression was negatively correlated with trkA expression, being lower in visceral afferents compared with cutaneous afferents (29% and 43%, respectively). The results emphasise the heterogeneity of trkA expression (and hence nerve growth factor, sensitivity) in afferents innervating different targets, and furthermore suggest that it is predominantly the CGRP-expressing population of primary afferents that express trkA.
first_indexed 2024-03-06T22:10:33Z
format Journal article
id oxford-uuid:51a7e01c-39df-4d54-a284-d7dba75724c6
institution University of Oxford
language English
last_indexed 2024-03-06T22:10:33Z
publishDate 1996
record_format dspace
spelling oxford-uuid:51a7e01c-39df-4d54-a284-d7dba75724c62022-03-26T16:21:00ZtrkA, CGRP and IB4 expression in retrogradely labelled cutaneous and visceral primary sensory neurones in the rat.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:51a7e01c-39df-4d54-a284-d7dba75724c6EnglishSymplectic Elements at Oxford1996Bennett, DDmietrieva, NPriestley, JClary, DMcMahon, SThe pattern of trkA expression in relation to other neurochemical markers (CGRP and IB4) was investigated in primary sensory neurones innervating either the skin or bladder. Retrograde tracing using the fluorescent marker Fast Blue was performed followed by histochemistry. A greater proportion of visceral afferents compared with cutaneous afferents were trkA-immunoreactive (75% and 43%, respectively). CGRP expression correlated with trkA expression in that it was higher in visceral afferents than cutaneous afferents (69% and 51%, respectively). IB4 expression was negatively correlated with trkA expression, being lower in visceral afferents compared with cutaneous afferents (29% and 43%, respectively). The results emphasise the heterogeneity of trkA expression (and hence nerve growth factor, sensitivity) in afferents innervating different targets, and furthermore suggest that it is predominantly the CGRP-expressing population of primary afferents that express trkA.
spellingShingle Bennett, D
Dmietrieva, N
Priestley, J
Clary, D
McMahon, S
trkA, CGRP and IB4 expression in retrogradely labelled cutaneous and visceral primary sensory neurones in the rat.
title trkA, CGRP and IB4 expression in retrogradely labelled cutaneous and visceral primary sensory neurones in the rat.
title_full trkA, CGRP and IB4 expression in retrogradely labelled cutaneous and visceral primary sensory neurones in the rat.
title_fullStr trkA, CGRP and IB4 expression in retrogradely labelled cutaneous and visceral primary sensory neurones in the rat.
title_full_unstemmed trkA, CGRP and IB4 expression in retrogradely labelled cutaneous and visceral primary sensory neurones in the rat.
title_short trkA, CGRP and IB4 expression in retrogradely labelled cutaneous and visceral primary sensory neurones in the rat.
title_sort trka cgrp and ib4 expression in retrogradely labelled cutaneous and visceral primary sensory neurones in the rat
work_keys_str_mv AT bennettd trkacgrpandib4expressioninretrogradelylabelledcutaneousandvisceralprimarysensoryneuronesintherat
AT dmietrievan trkacgrpandib4expressioninretrogradelylabelledcutaneousandvisceralprimarysensoryneuronesintherat
AT priestleyj trkacgrpandib4expressioninretrogradelylabelledcutaneousandvisceralprimarysensoryneuronesintherat
AT claryd trkacgrpandib4expressioninretrogradelylabelledcutaneousandvisceralprimarysensoryneuronesintherat
AT mcmahons trkacgrpandib4expressioninretrogradelylabelledcutaneousandvisceralprimarysensoryneuronesintherat