The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway
The identification of cancer-associated mutations in the tricarboxylic acid (TCA) cycle enzymes isocitrate dehydrogenases 1 and 2 (IDH1/2) highlights the prevailing notion that aberrant metabolic function can contribute to carcinogenesis. IDH1/2 normally catalyse the oxidative decarboxylation of iso...
| Główni autorzy: | , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Język: | English |
| Wydane: |
Springer Nature
2016
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