Functional diversity of macrophages in vascular biology and disease
Atherosclerosis is a multifactorial chronic inflammatory disease and is largely responsible for cardiovascular disease, the most common cause of global mortality. The hallmark of atherogenesis is immune activation following lipid accumulation in the arterial wall. In particular, macrophages play a n...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2017
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| _version_ | 1797068433423073280 |
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| author | Park, I Kassiteridi, C Monaco, C |
| author_facet | Park, I Kassiteridi, C Monaco, C |
| author_sort | Park, I |
| collection | OXFORD |
| description | Atherosclerosis is a multifactorial chronic inflammatory disease and is largely responsible for cardiovascular disease, the most common cause of global mortality. The hallmark of atherogenesis is immune activation following lipid accumulation in the arterial wall. In particular, macrophages play a non-redundant role in both the progression and regression of inflammation in the atherosclerotic lesion. Macrophages are remarkably heterogeneous phagocytes that perform versatile functions in health and disease. Their functional diversity in vascular biology is only partially mapped. Targeting macrophages is often highlighted as a therapeutic approach for cancer, metabolic and inflammatory diseases. Future strategies for therapeutic intervention in atherosclerosis may benefit from attempts to reduce local proliferation of pro-inflammatory macrophage subsets or enhance resolution of inflammation. Thus, characterisation of macrophage subsets during atherosclerosis would empower clinical interventions. Therefore, it would be of fundamental importance to understand how pathological factors modulate macrophage activity in order to exploit their use in the treatment of atherosclerosis and other diseases. |
| first_indexed | 2024-03-06T22:10:43Z |
| format | Journal article |
| id | oxford-uuid:51b4cb72-c232-4820-b789-57d7110e39a2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:10:43Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:51b4cb72-c232-4820-b789-57d7110e39a22022-03-26T16:21:13ZFunctional diversity of macrophages in vascular biology and diseaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:51b4cb72-c232-4820-b789-57d7110e39a2EnglishSymplectic Elements at OxfordElsevier2017Park, IKassiteridi, CMonaco, CAtherosclerosis is a multifactorial chronic inflammatory disease and is largely responsible for cardiovascular disease, the most common cause of global mortality. The hallmark of atherogenesis is immune activation following lipid accumulation in the arterial wall. In particular, macrophages play a non-redundant role in both the progression and regression of inflammation in the atherosclerotic lesion. Macrophages are remarkably heterogeneous phagocytes that perform versatile functions in health and disease. Their functional diversity in vascular biology is only partially mapped. Targeting macrophages is often highlighted as a therapeutic approach for cancer, metabolic and inflammatory diseases. Future strategies for therapeutic intervention in atherosclerosis may benefit from attempts to reduce local proliferation of pro-inflammatory macrophage subsets or enhance resolution of inflammation. Thus, characterisation of macrophage subsets during atherosclerosis would empower clinical interventions. Therefore, it would be of fundamental importance to understand how pathological factors modulate macrophage activity in order to exploit their use in the treatment of atherosclerosis and other diseases. |
| spellingShingle | Park, I Kassiteridi, C Monaco, C Functional diversity of macrophages in vascular biology and disease |
| title | Functional diversity of macrophages in vascular biology and disease |
| title_full | Functional diversity of macrophages in vascular biology and disease |
| title_fullStr | Functional diversity of macrophages in vascular biology and disease |
| title_full_unstemmed | Functional diversity of macrophages in vascular biology and disease |
| title_short | Functional diversity of macrophages in vascular biology and disease |
| title_sort | functional diversity of macrophages in vascular biology and disease |
| work_keys_str_mv | AT parki functionaldiversityofmacrophagesinvascularbiologyanddisease AT kassiteridic functionaldiversityofmacrophagesinvascularbiologyanddisease AT monacoc functionaldiversityofmacrophagesinvascularbiologyanddisease |