Risk of new vertebral fracture in the year following a fracture.
CONTEXT: Vertebral fractures significantly increase lifetime risk of future fractures, but risk of further vertebral fractures in the period immediately following a vertebral fracture has not been evaluated. OBJECTIVE: To determine the incidence of further vertebral fracture in the year following a...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2001
|
| _version_ | 1797068461693730816 |
|---|---|
| author | Lindsay, R Silverman, S Cooper, C Hanley, D Barton, I Broy, S Licata, A Benhamou, L Geusens, P Flowers, K Stracke, H Seeman, E |
| author_facet | Lindsay, R Silverman, S Cooper, C Hanley, D Barton, I Broy, S Licata, A Benhamou, L Geusens, P Flowers, K Stracke, H Seeman, E |
| author_sort | Lindsay, R |
| collection | OXFORD |
| description | CONTEXT: Vertebral fractures significantly increase lifetime risk of future fractures, but risk of further vertebral fractures in the period immediately following a vertebral fracture has not been evaluated. OBJECTIVE: To determine the incidence of further vertebral fracture in the year following a vertebral fracture. DESIGN AND SETTING: Analysis of data from 4 large 3-year osteoporosis treatment trials conducted at 373 study centers in North America, Europe, Australia, and New Zealand from November 1993 to April 1998. SUBJECTS: Postmenopausal women who had been randomized to a placebo group and for whom vertebral fracture status was known at entry (n = 2725). MAIN OUTCOME MEASURE: Occurrence of radiographically identified vertebral fracture during the year following an incident vertebral fracture. RESULTS: Subjects were a mean age of 74 years and had a mean of 28 years since menopause. The cumulative incidence of new vertebral fractures in the first year was 6.6%. Presence of 1 or more vertebral fractures at baseline increased risk of sustaining a vertebral fracture by 5-fold during the initial year of the study compared with the incidence in subjects without prevalent vertebral fractures at baseline (relative risk [RR], 5.1; 95% confidence interval [CI], 3.1-8.4; P<.001). Among the 381 participants who developed an incident vertebral fracture, the incidence of a new vertebral fracture in the subsequent year was 19.2% (95% CI, 13.6%-24.8%). This risk was also increased in the presence of prevalent vertebral fractures (RR, 9.3; 95% CI, 1.2-71.6; P =.03). CONCLUSION: Our data indicate that women who develop a vertebral fracture are at substantial risk for additional fracture within the next year. |
| first_indexed | 2024-03-06T22:11:08Z |
| format | Journal article |
| id | oxford-uuid:51d949aa-83db-484b-822a-cceeef289276 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:11:08Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:51d949aa-83db-484b-822a-cceeef2892762022-03-26T16:22:02ZRisk of new vertebral fracture in the year following a fracture.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:51d949aa-83db-484b-822a-cceeef289276EnglishSymplectic Elements at Oxford2001Lindsay, RSilverman, SCooper, CHanley, DBarton, IBroy, SLicata, ABenhamou, LGeusens, PFlowers, KStracke, HSeeman, ECONTEXT: Vertebral fractures significantly increase lifetime risk of future fractures, but risk of further vertebral fractures in the period immediately following a vertebral fracture has not been evaluated. OBJECTIVE: To determine the incidence of further vertebral fracture in the year following a vertebral fracture. DESIGN AND SETTING: Analysis of data from 4 large 3-year osteoporosis treatment trials conducted at 373 study centers in North America, Europe, Australia, and New Zealand from November 1993 to April 1998. SUBJECTS: Postmenopausal women who had been randomized to a placebo group and for whom vertebral fracture status was known at entry (n = 2725). MAIN OUTCOME MEASURE: Occurrence of radiographically identified vertebral fracture during the year following an incident vertebral fracture. RESULTS: Subjects were a mean age of 74 years and had a mean of 28 years since menopause. The cumulative incidence of new vertebral fractures in the first year was 6.6%. Presence of 1 or more vertebral fractures at baseline increased risk of sustaining a vertebral fracture by 5-fold during the initial year of the study compared with the incidence in subjects without prevalent vertebral fractures at baseline (relative risk [RR], 5.1; 95% confidence interval [CI], 3.1-8.4; P<.001). Among the 381 participants who developed an incident vertebral fracture, the incidence of a new vertebral fracture in the subsequent year was 19.2% (95% CI, 13.6%-24.8%). This risk was also increased in the presence of prevalent vertebral fractures (RR, 9.3; 95% CI, 1.2-71.6; P =.03). CONCLUSION: Our data indicate that women who develop a vertebral fracture are at substantial risk for additional fracture within the next year. |
| spellingShingle | Lindsay, R Silverman, S Cooper, C Hanley, D Barton, I Broy, S Licata, A Benhamou, L Geusens, P Flowers, K Stracke, H Seeman, E Risk of new vertebral fracture in the year following a fracture. |
| title | Risk of new vertebral fracture in the year following a fracture. |
| title_full | Risk of new vertebral fracture in the year following a fracture. |
| title_fullStr | Risk of new vertebral fracture in the year following a fracture. |
| title_full_unstemmed | Risk of new vertebral fracture in the year following a fracture. |
| title_short | Risk of new vertebral fracture in the year following a fracture. |
| title_sort | risk of new vertebral fracture in the year following a fracture |
| work_keys_str_mv | AT lindsayr riskofnewvertebralfractureintheyearfollowingafracture AT silvermans riskofnewvertebralfractureintheyearfollowingafracture AT cooperc riskofnewvertebralfractureintheyearfollowingafracture AT hanleyd riskofnewvertebralfractureintheyearfollowingafracture AT bartoni riskofnewvertebralfractureintheyearfollowingafracture AT broys riskofnewvertebralfractureintheyearfollowingafracture AT licataa riskofnewvertebralfractureintheyearfollowingafracture AT benhamoul riskofnewvertebralfractureintheyearfollowingafracture AT geusensp riskofnewvertebralfractureintheyearfollowingafracture AT flowersk riskofnewvertebralfractureintheyearfollowingafracture AT strackeh riskofnewvertebralfractureintheyearfollowingafracture AT seemane riskofnewvertebralfractureintheyearfollowingafracture |