Chromium treatment decreases the sensitivity of 5-HT2A receptors.
RATIONALE: Recent case series suggest that chromium picolinate in doses of 400 microg daily may have antidepressant properties, perhaps through increasing the peripheral availability of tryptophan for brain serotonin (5-HT) synthesis. OBJECTIVES: To determine the effects of chromium treatment on pla...
| 主要な著者: | , , , , |
|---|---|
| フォーマット: | Journal article |
| 言語: | English |
| 出版事項: |
2002
|
| _version_ | 1826272370458886144 |
|---|---|
| author | Attenburrow, M Odontiadis, J Murray, B Cowen, P Franklin, M |
| author_facet | Attenburrow, M Odontiadis, J Murray, B Cowen, P Franklin, M |
| author_sort | Attenburrow, M |
| collection | OXFORD |
| description | RATIONALE: Recent case series suggest that chromium picolinate in doses of 400 microg daily may have antidepressant properties, perhaps through increasing the peripheral availability of tryptophan for brain serotonin (5-HT) synthesis. OBJECTIVES: To determine the effects of chromium treatment on plasma tryptophan availability and on brain 5-HT function in human and animal models. METHODS: We studied the effects of short-term chromium supplementation on plasma concentrations of tryptophan and other large neutral amino acids. Brain 5-HT function was assessed by measuring the corticosterone/cortisol response to the 5-HT precursor, 5-hydroxytryptophan (5-HTP), a response believed to be mediated via indirect activation of 5-HT(2A) receptors. RESULTS: In rats, chromium increased peripheral and central tryptophan availability and elevated brain 5-HT content. Changes in peripheral tryptophan availability were not seen in humans but in both rats and humans, chromium lowered the cortisol response to challenge with 5-HTP. CONCLUSIONS: Chromium can modify brain 5-HT function in humans and animals, perhaps by altering the sensitivity of central 5-HT(2A) receptors. |
| first_indexed | 2024-03-06T22:11:29Z |
| format | Journal article |
| id | oxford-uuid:51f4f1fb-08b0-4bb9-9d0a-5ca61949f45a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:11:29Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:51f4f1fb-08b0-4bb9-9d0a-5ca61949f45a2022-03-26T16:22:45ZChromium treatment decreases the sensitivity of 5-HT2A receptors.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:51f4f1fb-08b0-4bb9-9d0a-5ca61949f45aEnglishSymplectic Elements at Oxford2002Attenburrow, MOdontiadis, JMurray, BCowen, PFranklin, MRATIONALE: Recent case series suggest that chromium picolinate in doses of 400 microg daily may have antidepressant properties, perhaps through increasing the peripheral availability of tryptophan for brain serotonin (5-HT) synthesis. OBJECTIVES: To determine the effects of chromium treatment on plasma tryptophan availability and on brain 5-HT function in human and animal models. METHODS: We studied the effects of short-term chromium supplementation on plasma concentrations of tryptophan and other large neutral amino acids. Brain 5-HT function was assessed by measuring the corticosterone/cortisol response to the 5-HT precursor, 5-hydroxytryptophan (5-HTP), a response believed to be mediated via indirect activation of 5-HT(2A) receptors. RESULTS: In rats, chromium increased peripheral and central tryptophan availability and elevated brain 5-HT content. Changes in peripheral tryptophan availability were not seen in humans but in both rats and humans, chromium lowered the cortisol response to challenge with 5-HTP. CONCLUSIONS: Chromium can modify brain 5-HT function in humans and animals, perhaps by altering the sensitivity of central 5-HT(2A) receptors. |
| spellingShingle | Attenburrow, M Odontiadis, J Murray, B Cowen, P Franklin, M Chromium treatment decreases the sensitivity of 5-HT2A receptors. |
| title | Chromium treatment decreases the sensitivity of 5-HT2A receptors. |
| title_full | Chromium treatment decreases the sensitivity of 5-HT2A receptors. |
| title_fullStr | Chromium treatment decreases the sensitivity of 5-HT2A receptors. |
| title_full_unstemmed | Chromium treatment decreases the sensitivity of 5-HT2A receptors. |
| title_short | Chromium treatment decreases the sensitivity of 5-HT2A receptors. |
| title_sort | chromium treatment decreases the sensitivity of 5 ht2a receptors |
| work_keys_str_mv | AT attenburrowm chromiumtreatmentdecreasesthesensitivityof5ht2areceptors AT odontiadisj chromiumtreatmentdecreasesthesensitivityof5ht2areceptors AT murrayb chromiumtreatmentdecreasesthesensitivityof5ht2areceptors AT cowenp chromiumtreatmentdecreasesthesensitivityof5ht2areceptors AT franklinm chromiumtreatmentdecreasesthesensitivityof5ht2areceptors |